N3143
萘啶酸 钠盐
powder
别名:
1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸 钠盐
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关于此项目
经验公式（希尔记法）:
C12H11N2NaO3
化学文摘社编号:
分子量:
254.22
Beilstein:
3580062
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
无菌性
γ-irradiated
表单
powder
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
DNA synthesis | interferes
enzyme | inhibits
SMILES字符串
[Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12
InChI
1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
InChI key
ROKRAUFZFDQWLE-UHFFFAOYSA-M
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一般描述
Chemical structure: quinolone
应用
Recommended for use in molecular biology applications at 15 μg/ml
生化/生理作用
萘啶酸钠盐是细菌 DNA 聚合酶（DNA 旋转酶）和禽髓母细胞瘤病毒逆转录酶的抑制剂。在 酿酒酵母中抑制核酸和蛋白质合成。
制备说明
Prepare stock solutions directly in the vial with sterile water (5-50 mg/ml). Stock solutions should be stored at −20 °C.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Anna Duse et al.
Journal of dairy science, 98(9), 6387-6398 (2015-07-21)
Quinolone resistance may emerge in gut bacteria (e.g., in Escherichia coli) of animals. Such bacteria could cause infections in the animal itself or be transmitted to humans via the food chain. Quinolone resistance is also observed in fecal E. coli
Xiangqun Fan et al.
Environmental science and pollution research international, 20(6), 3649-3656 (2012-11-07)
The Fenton-like degradation of nalidixic acid was studied in this work. The effects of Fe(3+) concentration and initial H(2)O(2) concentration were investigated. Increasing the initial H(2)O(2) concentration enhances the degradation and mineralization efficiency for nalidixic acid, while Fe(3+) shows an
Mohamed Nawaz et al.
International journal of food microbiology, 155(3), 179-184 (2012-03-13)
A study was undertaken to isolate and characterize tetracycline and nalidixic acid-resistant Klebsiella spp. in farm-raised, imported shrimp sold in the United States. Sixty-seven multiple antibiotic-resistant Klebsiella spp. strains were isolated from imported shrimp samples. Using morphological and biochemical methods
Jing Wang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14631-14644 (2020-09-13)
During spaceflight, astronauts are subjected to various physical stressors including microgravity, which could cause immune dysfunction and thus potentially predispose astronauts to infections and illness. However, the mechanisms by which microgravity affects innate immunity remain largely unclear. In this study
Atefeh Abouzarzadeh et al.
Journal of molecular recognition : JMR, 25(7), 404-413 (2012-06-27)
For the first time in this work, uniform molecularly imprinted polymer (MIP) nanoparticles were prepared using nalidixic acid as a template. The MIP nanoparticles were successfully synthesized by precipitation polymerization applying methacrylic acid (MAA) as a functional monomer and trimethylolpropane
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