N3143
萘啶酸 钠盐
powder
别名:
1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸 钠盐
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关于此项目
经验公式（希尔记法）:
C12H11N2NaO3
化学文摘社编号:
分子量:
254.22
EC Number:
222-159-7
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
3580062
MDL number:
InChI key
ROKRAUFZFDQWLE-UHFFFAOYSA-M
InChI
1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
SMILES string
[Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12
sterility
γ-irradiated
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
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General description
Chemical structure: quinolone
Application
Recommended for use in molecular biology applications at 15 μg/ml
Biochem/physiol Actions
萘啶酸钠盐是细菌 DNA 聚合酶（DNA 旋转酶）和禽髓母细胞瘤病毒逆转录酶的抑制剂。在 酿酒酵母中抑制核酸和蛋白质合成。
Preparation Note
Prepare stock solutions directly in the vial with sterile water (5-50 mg/ml). Stock solutions should be stored at −20 °C.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Anna Duse et al.
Journal of dairy science, 98(9), 6387-6398 (2015-07-21)
Quinolone resistance may emerge in gut bacteria (e.g., in Escherichia coli) of animals. Such bacteria could cause infections in the animal itself or be transmitted to humans via the food chain. Quinolone resistance is also observed in fecal E. coli
Jing Wang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14631-14644 (2020-09-13)
During spaceflight, astronauts are subjected to various physical stressors including microgravity, which could cause immune dysfunction and thus potentially predispose astronauts to infections and illness. However, the mechanisms by which microgravity affects innate immunity remain largely unclear. In this study
Robert J Commons et al.
The Medical journal of Australia, 196(5), 332-336 (2012-03-22)
To determine incidence and trends in antibiotic resistance in Australian Salmonella enterica subspecies enterica serovars Typhi (S. Typhi) and Paratyphi (S. Paratyphi) isolates over the past 26 years. A retrospective analysis of consecutive microbiologically confirmed enteric fever isolates. All S.
Dimitrios Farmakiotis et al.
Journal of travel medicine, 20(1), 17-21 (2013-01-03)
Typhoid is a leading cause of fever in returning travelers. The prevalence is highest in migrants visiting friends and relatives (VFR travelers) in the Indian subcontinent, where reports of resistance have been of concern. This study is a retrospective analysis
Migla Miskinyte et al.
Antimicrobial agents and chemotherapy, 57(1), 189-195 (2012-10-24)
Mutations causing antibiotic resistance usually incur a fitness cost in the absence of antibiotics. The magnitude of such costs is known to vary with the environment. Little is known about the fitness effects of antibiotic resistance mutations when bacteria confront
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