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Merck
CN

N3376

Sigma-Aldrich

烟酰胺

≥98% (HPLC), powder, PARP inhibitor

别名:

吡啶-3-甲酰胺, 烟碱酰胺, 烟酰胺, 维生素 B3, 维生素 PP

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关于此项目

经验公式（希尔记法）:
C6H6N2O
化学文摘社编号:
98-92-0
分子量:
122.12
Beilstein:
383619
EC 号:
202-713-4
MDL编号:
MFCD00006395
UNSPSC代码:
12352200
PubChem化学物质编号:
24897638
NACRES:
NA.77

主要文件

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产品名称

烟酰胺, ≥98% (HPLC), powder

质量水平

200

方案

≥98% (HPLC)

表单

powder

颜色

white

mp

128-131 °C (lit.)

应用

cell analysis

SMILES字符串

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

基因信息

human ... PARP1(142), SIRT2(22933)

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相关类别

应用

用作某些酶的辅助因子

生化/生理作用

烟酰胺是维生素B3的酰胺衍生物，是PARP抑制剂

特点和优势

该化合物是基因调控研究推荐产品。点击此处 ，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

制备说明

本品可在室温和干燥条件下密封保存。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

302.0 °F - closed cup

闪点(°C)

150 °C - closed cup

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000479368
0000479368
0000477327
0000477327
0000477056

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Christian W Johnson et al.
Cell reports, 28(6), 1538-1550 (2019-08-08)
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or
Ann-Lii Cheng et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(32), 4067-4075 (2013-10-02)
Open-label, phase III trial evaluating whether sunitinib was superior or equivalent to sorafenib in hepatocellular cancer. Patients were stratified and randomly assigned to receive sunitinib 37.5 mg once per day or sorafenib 400 mg twice per day. Primary end point
Thomas J Herzog et al.
Gynecologic oncology, 130(1), 25-30 (2013-04-18)
Sorafenib, an oral multikinase inhibitor of the VEGFR/PDGFR/Raf/MEK/ERK pathway, has shown potential activity in patients with recurrent ovarian cancer (OC). One strategy to prolong disease control and survival in patients with OC is maintenance therapy after achieving a complete response.
Kathrin Schmeisser et al.
Nature chemical biology, 9(11), 693-700 (2013-10-01)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan. In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog of mammalian SirT1, does extend Caenorhabditis elegans lifespan. Sirtuins mandatorily convert NAD(+)
Robert J Motzer et al.
The Lancet. Oncology, 14(6), 552-562 (2013-04-20)
In a phase 3 trial comparing the efficacy and safety of axitinib versus sorafenib as second-line treatment for metastatic renal cell carcinoma, patients given axitinib had a longer progression-free survival (PFS). Here, we report overall survival and updated efficacy, quality
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