N3398
S-亚硝基-N-乙酰基-DL-青霉胺
≥97%, Nitric oxide donor, powder
别名:
N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸, S-亚硝基-N-乙酰青霉胺, SNAP
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关于此项目
经验公式（希尔记法）:
C7H12N2O4S
化学文摘社编号:
分子量:
220.25
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.32
产品名称
S-亚硝基-N-乙酰基-DL-青霉胺, ≥97%, powder
质量水平
方案
≥97%
表单
powder
颜色
faint green to very dark green
溶解性
H2O: ≥2 mg/mL
DMSO: ≥20 mg/mL, clear (faint green to very dark green)
储存温度
−20°C
SMILES字符串
CC(=O)NC(C(O)=O)C(C)(C)SN=O
InChI
1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)
InChI key
ZIIQCSMRQKCOCT-UHFFFAOYSA-N
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相关类别
应用
S-亚硝基-N-乙酰基-DL-青霉胺（SNAP）用于：
- 作为亚硝酸盐生成实验中的阳性对照。
- 阻断内源性转谷氨酰胺酶（TG2）的活性。
- 细胞增殖实验，在细胞培养物中产生一氧化氮(NO)。
生化/生理作用
NO供体；血管扩张剂、平滑肌松弛剂、淋巴细胞激活剂。 激活可溶性鸟苷酸环化酶。
SNAP是一种亚硝基硫醇衍生物，在生理条件下释放一氧化氮（NO），从而使其成为研究NO的药理学和生理学作用的有用工具。由于SNAP具有释放NO的特性，所有其在体内和体外均是有效的血管扩张剂，不易产生药理学耐受性。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction.
Eriksson U
Circulation, 103(1), 18-21 (2001)
Sophiya Garasia et al.
Scientific reports, 7(1), 1629-1629 (2017-05-11)
We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study.
Immunomodulatory activities of chitin microparticles on Leishmania major-infected murine macrophages.
Dehghani F
Archives of Medical Research, 42(7), 572-576 (2011)
Jodie D Anderson et al.
Journal of veterinary internal medicine, 33(4), 1593-1601 (2019-05-28)
Intravenous continuous rate infusion (IVCRI) of lispro at a starting dose of 0.09 U/kg/h and the use of 0.9% sodium chloride (NaCl) for fluid resuscitation in cats with diabetic ketoacidosis (DKA) have not been reported. Protocols for correction of electrolyte deficiencies
Zorana Milanović et al.
Journal of veterinary internal medicine, 33(4), 1686-1694 (2019-06-09)
Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Dogs with B. canis-induced APR develop dyslipidemia with altered lipoprotein concentration and morphology. Twenty-nine client-owned dogs
商品
一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
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