N3501
β-烟酰胺单核苷酸
≥95% (HPLC)
别名:
β-NMN, β-烟酰胺核糖单磷酸, NMN, 烟酰胺-1-ium-1-β-D-呋喃糖苷5′-磷酸, 烟酰胺核苷酸
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关于此项目
经验公式（希尔记法）:
C11H15N2O8P
化学文摘社编号:
分子量:
334.22
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
214-136-5
Beilstein/REAXYS Number:
3570187
MDL number:
产品名称
β-烟酰胺单核苷酸, ≥95% (HPLC)
InChI key
YYNOOWWEYJELSF-SEMCEJNYSA-N
InChI
1S/C13H19N2O6P/c1-8-9(2)13(21-11(8)7-20-22(17,18)19)15-5-3-4-10(6-15)12(14)16/h3-6,8-9,11,13H,7H2,1-2H3,(H3-,14,16,17,18,19)/t8-,9+,11+,13+/m0/s1
SMILES string
C[C@H]1[C@@H](C)[C@@H](O[C@@H]1COP(O)([O-])=O)[n+]2cccc(c2)C(N)=O
assay
≥95% (HPLC)
≥95% (spectrophotometric assay)
form
powder
solubility
H2O: soluble-50 mg/mL to clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
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Application
β-烟酰胺单核苷酸（NMN）用于研究过RNA适体的结合基元，和包含了β烟酰胺单核苷酸 (β-NMN)-活化RNA片段的核酸酶活化过程。
General description
β-烟酰胺单核苷酸 (β-NMN)是烟酰胺磷酸核糖基转移酶 (NAMPT)催化烟酰胺腺嘌呤二核苷酸 (NAD+)生物合成的中间体。 NAMPT可介导烟酰胺与5-磷酸核糖基-1-焦磷酸的缩合，生成β-NMN。 β-NMN腺苷酸转移酶随后将β-NMN转化为NAD+。
Other Notes
注：这是NMN常见形式。不要和 α-NMN混淆。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tomoko Kito et al.
Drug metabolism and pharmacokinetics, 34(1), 87-94 (2018-12-12)
The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic drug interactions with trimethoprim. Trimethoprim is a more potent inhibitor
Kazuhiro Hasegawa et al.
Nature medicine, 19(11), 1496-1504 (2013-10-22)
Sirtuin 1 (Sirt1), a NAD(+)-regulated deacetylase with numerous known positive effects on cellular and whole-body metabolism, is expressed in the renal cortex and medulla. It is known to have protective effects against age-related disease, including diabetes. Here we investigated the
João Meireles Ribeiro et al.
Scientific reports, 8(1), 1036-1036 (2018-01-20)
Cyclic ADP-ribose (cADPR) is a messenger for Ca
C T Lauhon et al.
Journal of the American Chemical Society, 117(4), 1246-1257 (1995-02-01)
RNA molecules that specifically bind riboflavin (Rb) and beta-nicotinamide mononucleotide (NMN) have been isolated by in vitro selection. A simple structural motif containing intramolecular G-quartets was found to bind tightly to oxidized riboflavin (Kd = 1-5 micromolar). DNA versions of
Gerwyn Morris et al.
Progress in neuro-psychopharmacology & biological psychiatry, 95, 109708-109708 (2019-07-28)
Major antioxidant responses to increased levels of inflammatory, oxidative and nitrosative stress (ONS) are detailed. In response to increasing levels of nitric oxide, S-nitrosylation of cysteine thiol groups leads to post-transcriptional modification of many cellular proteins and thereby regulates their
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