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N3538

那格列奈

Name: 那格列奈
Brand: SIGMA

≥98% (HPLC), solid

别名:

Fastic, N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine, Starlix, Starsis

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About This Item

经验公式（希尔记法）:

C₁₉H₂₇NO₃

CAS Number:

105816-04-4

分子量:

317.42

MDL编号:

MFCD00875706

UNSPSC代码:

12352200

PubChem化学物质编号:

329818636

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

solid

颜色

white to off-white

溶解性

DMSO: >5 mg/mL
H₂O: insoluble

创始人

Novartis

储存温度

room temp

SMILES字符串

CC(C)[C@@H]1CC[C@H](CC1)C(=O)N[C@H](Cc2ccccc2)C(O)=O

InChI

1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1

InChI key

OELFLUMRDSZNSF-BRWVUGGUSA-N

基因信息

human ... ABCC8(6833), KCNJ11(3767)

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生化/生理作用

Nateglinide is a K_ir6.2/SUR1 channel inhibitor and antidiabetic.

Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic. It is selective for the SUR1 subtype, which is found on pancreatic islet cells. Nateglinide evokes KATP channel-dependent insulin secretion (50-200 μM) in the absence and presence of insulin.

Nateglinide is a short-acting insulin secretagogue useful in treating type 2 diabetes. It is an insulinotropic agent effective for postprandial hyperglycemia. Nateglinide restores prandial insulin levels in a glucose-dependent manner.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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