N3539
尼可地尔
≥98% (HPLC)
别名:
2-(吡啶-3-羰基氨基)乙基硝酸酯, 2-烟酰胺基硝酸乙酯, N-[2-硝氧乙基]-3-吡啶键酰胺, SG-75, 尼可地尔, 烟浪丁
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经验公式（希尔记法）:
C8H9N3O4
化学文摘社编号:
分子量:
211.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
265-514-1
MDL number:
Application
尼古拉地尔已被用作钾（K +）通道激活剂和电压门控钙通道抑制剂，用于研究其对人类长QT综合征2（LQTS2）诱导的多能干细胞（hiPSCs）衍生的心肌细胞动作电位（action potential）的影响。
Biochem/physiol Actions
尼可地尔是一种杂合ATP敏感性K+（KATP）通道开放剂，也是烟酰胺硝酸盐NO供体。
尼可地尔是一种杂合ATP敏感性K+（KATP）通道开放剂，也是烟酰胺硝酸盐NO供体。尼可地尔能够选择性激活含有SUR2B-和SUR2A-的KATP通道。它可以增强内皮NO合酶的表达，并防止缺血性室性心律失常。尼可地尔通过激活钾离子通道并提供一氧化氮激活鸟苷酸环化酶，引起GMP活化，从而导致动脉和静脉血管舒张。尼可地尔对血管钾离子通道具有选择性，但对心肌收缩和传导没有明显作用。
尼可地尔（Nicorandil ）具有心脏保护作用。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Org. Perox. D
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A Markham et al.
Drugs, 60(4), 955-974 (2000-11-21)
Nicorandil is a drug with both nitrate-like and ATP-sensitive potassium-channel (K+ ATP) activating properties. By virtue of this dual mechanism of action, the drug acts as a balanced coronary and peripheral vasodilator and reduces both preload and afterload. The K+
L Toquero et al.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 8(8), 717-720 (2006-09-15)
Use of Nicorandil in the treatment of ischaemic heart disease has been associated with oral, ileal and more recently anal ulceration. We report a series of six cases of peri-anal ulceration in patients on nicorandil therapy, their response to withdrawal
V M Smith et al.
The British journal of dermatology, 167(5), 1048-1052 (2012-10-09)
Nicorandil has been available in the U.K. since 1994 for the prophylaxis and treatment of angina. Since the first reported case of nicorandil-associated oral ulceration in 1997 complications elsewhere in the gastrointestinal tract have been reported. Our case series highlights
Clinical trials update: The Heart Protection Study, IONA, CARISA, ENRICHD, ACUTE, ALIVE, MADIT II and REMATCH. Impact Of Nicorandil on Angina. Combination Assessment of Ranolazine In Stable Angina. ENhancing Recovery In Coronary Heart Disease patients. Assessment of Cardioversion Using Transoesophageal Echocardiography. AzimiLide post-Infarct surVival Evaluation. Randomised Evaluation of Mechanical Assistance for Treatment of Chronic Heart failure.
Amala A Louis et al.
European journal of heart failure, 4(1), 111-116 (2002-01-29)
Lamiaa A Ahmed et al.
Biochemical pharmacology, 86(9), 1301-1310 (2013-07-23)
Despite of its known cardiotoxicity, doxorubicin is still a highly effective anti-neoplastic agent in the treatment of several cancers. In the present study, the cardioprotective effect of nicorandil was investigated on hemodynamic alterations and mitochondrial dysfunction induced by cumulative administration
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