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经验公式(希尔记法):
C8H9N3O4
化学文摘社编号:
分子量:
211.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
265-514-1
MDL number:
Application
尼古拉地尔已被用作钾(K +)通道激活剂和电压门控钙通道抑制剂,用于研究其对人类长QT综合征2(LQTS2)诱导的多能干细胞(hiPSCs)衍生的心肌细胞动作电位(action potential)的影响。
Biochem/physiol Actions
尼可地尔是一种杂合ATP敏感性K+(KATP)通道开放剂,也是烟酰胺硝酸盐NO供体。
尼可地尔是一种杂合ATP敏感性K+(KATP)通道开放剂,也是烟酰胺硝酸盐NO供体。尼可地尔能够选择性激活含有SUR2B-和SUR2A-的KATP通道。它可以增强内皮NO合酶的表达,并防止缺血性室性心律失常。尼可地尔通过激活钾离子通道并提供一氧化氮激活鸟苷酸环化酶,引起GMP活化,从而导致动脉和静脉血管舒张。尼可地尔对血管钾离子通道具有选择性,但对心肌收缩和传导没有明显作用。
尼可地尔(Nicorandil )具有心脏保护作用。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Org. Perox. D
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A H Gomma et al.
Drugs, 61(12), 1705-1710 (2001-11-06)
Potassium channel openers or agonists represent a novel new class of compounds in the treatment of a range of cardiovascular disorders, particularly angina pectoris and hypertension. Nicorandil is the only clinically available potassium channel opener with antianginal effects, and with
Dene Simpson et al.
Drugs, 64(17), 1941-1955 (2004-08-27)
Nicorandil (Adancor, Angicor, Dancor, Nikoril [Europe], Ikorel [Europe and Oceania], Sigmart [Japan, Korea and Taiwan]) is an adenosine triphosphate (ATP)-sensitive potassium (KATP) channel agonist with nitrate-like properties used in the management of stable angina pectoris. With well established monotherapeutic antianginal
Nicorandil: a drug for many purposes: too good to be true?
Eeckhout E
European heart journal (2003)
Lamiaa A Ahmed et al.
Biochemical pharmacology, 86(9), 1301-1310 (2013-07-23)
Despite of its known cardiotoxicity, doxorubicin is still a highly effective anti-neoplastic agent in the treatment of several cancers. In the present study, the cardioprotective effect of nicorandil was investigated on hemodynamic alterations and mitochondrial dysfunction induced by cumulative administration
V M Smith et al.
The British journal of dermatology, 167(5), 1048-1052 (2012-10-09)
Nicorandil has been available in the U.K. since 1994 for the prophylaxis and treatment of angina. Since the first reported case of nicorandil-associated oral ulceration in 1997 complications elsewhere in the gastrointestinal tract have been reported. Our case series highlights
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