N3762
Neuromedin B
≥90% (HPLC)
登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C52H73N15O12S
化学文摘社编号:
分子量:
1132.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥90% (HPLC)
Form:
powder
Quality Segment
assay
≥90% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2cnc[nH]2)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)CN)C(C)O)C(N)=O
InChI
1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)
InChI key
YPFNACALNKVZNK-UHFFFAOYSA-N
General description
Neuromedin B (NMB) belongs to the bombesin (BN)-like peptide family in mammals. It is located in the gastrointestinal tract and central nervous system.
Application
Neuromedin B (NMB) has been used as a bombesin (BN)-like peptide:
- for injection in mice to understand energy expenditure and oxygen consumption and CO2 production
- to study its effects on the thyrotropin (TSH) and prolactin (PRL) release in vitro
- to analyze its effects on angiogenesis through the activation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in endothelial cells
Biochem/physiol Actions
Neuromedin B (NMB) exhibits its effects by binding to the cell surface receptors. It facilitates its action on several contractile organs including, the stomach, intestine, esophagus, gall bladder, urinary bladder, and uterus. It also plays a role in food intake, hypothermia, and thermoregulation. NMB is involved in exocrine and endocrine secretion of gastrin, insulin, cholecystokinin, enteroglucagon, and gastric inhibitory peptide. It also acts as an autocrine growth factor in non-small cell lung cancer.
Features and Benefits
This compound is featured on the Bombesin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)