Name: Neuromedin B
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₅₂H₇₃N₁₅O₁₂S

CAS Number:

87096-84-2

分子量:

1132.29

MDL编号:

MFCD00167607

UNSPSC代码:

12352200

PubChem化学物质编号:

24897661

NACRES:

NA.77

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质量水平

100

方案

≥90% (HPLC)

表单

powder

储存温度

−20°C

SMILES字符串

CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2cnc[nH]2)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)CN)C(C)O)C(N)=O

InChI

1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)

InChI key

YPFNACALNKVZNK-UHFFFAOYSA-N

Amino Acid Sequence

Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2

一般描述

Neuromedin B (NMB) belongs to the bombesin (BN)-like peptide family in mammals. It is located in the gastrointestinal tract and central nervous system.

应用

Neuromedin B (NMB) has been used as a bombesin (BN)-like peptide:

for injection in mice to understand energy expenditure and oxygen consumption and CO2 production
to study its effects on the thyrotropin (TSH) and prolactin (PRL) release in vitro
to analyze its effects on angiogenesis through the activation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) in endothelial cells

生化/生理作用

Neuromedin B (NMB) exhibits its effects by binding to the cell surface receptors. It facilitates its action on several contractile organs including, the stomach, intestine, esophagus, gall bladder, urinary bladder, and uterus. It also plays a role in food intake, hypothermia, and thermoregulation. NMB is involved in exocrine and endocrine secretion of gastrin, insulin, cholecystokinin, enteroglucagon, and gastric inhibitory peptide. It also acts as an autocrine growth factor in non-small cell lung cancer.

特点和优势

This compound is featured on the Bombesin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.