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Merck
CN

N4014

制霉菌素即用型溶液

powder, suitable for cell culture, BioXtra

别名:

制霉素, 制霉菌素

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关于此项目

化学文摘社编号:
1400-61-9
NACRES:
NA.76
PubChem Substance ID:
24897362
UNSPSC Code:
12352207
EC Number:
215-749-0
MDL number:
MFCD25541651

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产品名称

制霉菌素即用型溶液, powder, γ-irradiated, BioXtra, suitable for cell culture

InChI key

VQOXZBDYSJBXMA-QEKUPDCNSA-N

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

SMILES string

O[C@@H]([C@H](C)[C@H](C)O1)[C@@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](O)(O3)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC1=O

sterility

γ-irradiated

product line

BioXtra

form

powder

mol wt

926.1 g/mol

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

fungi
yeast

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

制霉菌素是一种多烯类抗生素。 用途包括预防培养细胞污染，诱导表达TLR2的THP1细胞分泌白介素（IL）-1、IL-8和肿瘤坏死因子α。 该产品的推荐细胞培养使用浓度为50 mg/L。

Biochem/physiol Actions

作用机制：制霉菌素通过与真菌细胞膜中的麦角甾醇结合，增加膜的渗透性和产生基于制霉菌素/麦角甾醇的离子通道起作用。 它还可作为脂筏抑制剂和膜相关胆固醇。

抗菌谱：制霉菌素可对抗真菌、酵母和霉菌。

Disclaimer

制霉菌素的组织培养基溶液在37°C下可稳定保存三天。 在中等碱性介质中也很稳定。 溶液和水悬液在制备后不久就开始失去活性，热、光和氧气会加速分解。 如果在pH 7下加热至100°C，水悬液可稳定保存10 min。

General description

化学结构：多烯

Other Notes

将容器密闭保存在干燥和通风良好的地方。在惰性气体下保存。对空气和光敏感。在干燥处保存。

Preparation Note

在28 °C，制霉菌素可溶于甲醇（11.2 mg/mL）、乙醇（1.2 mg/mL）、四氯化碳（1.23 mg/mL）、氯仿（0.48 mg/mL）、苯（0.28 mg/mL）和乙二醇（8.75 mg/mL）。 也可以5 mg/mL溶于DMSO，易溶于DMF和甲酰胺。 不建议对制霉菌素溶液进行高压灭菌或无菌过滤。 制霉菌素混悬液也有效，37 °C下可稳定保存3天。 制备50 mg/mL的储备混悬液，-20°C下保存。对N6261进行γ-辐照得该产品。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000420041
0000420041
SLCL9367
SLCJ0744
SLCC5256

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