N4256
烟酸腺嘌呤二核苷酸 钠盐
≥98%
别名:
NAAD, NAAD钠盐, 烟酸NAD, 烟酸腺嘌呤二核苷酸钠盐, 脱酰氨NAD, 脱酰氨NAD钠盐
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关于此项目
经验公式（希尔记法）:
C21H25N6O15P2Na
化学文摘社编号:
分子量:
686.39
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Form:
powder
Assay:
≥98%
Solubility:
H2O: soluble-50 mg/mL, clear, colorless
Biological source:
synthetic (inorganic)
产品名称
烟酸腺嘌呤二核苷酸 钠盐, ≥98%
InChI
1S/C21H27N6O15P2.Na.H/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33;;/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H,32,33)(H,34,35)(H,36,37)(H2,22,23,24);;
SMILES string
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC4OC(C(O)C4O)[N]5=CC(=CC=C5)C(O)=O)C(O)C3O
InChI key
JSOFOHZYBCRUNK-UHFFFAOYSA-N
biological source
synthetic (inorganic)
assay
≥98%
form
powder
solubility
H2O: soluble-50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Application
烟酸腺嘌呤二核苷酸钠盐已被用作高效液相色谱（HPLC）代谢物测定的内标物。它还被用作烟酰胺腺嘌呤二核苷酸（NAD）生物合成的底物。
General description
烟酸腺嘌呤二核苷酸（deamido-NAD、NAAD）是与NAD+密切相关的类似物。它用于研究烟酸单核苷酸腺苷转移酶（NMN/NaMN）的结构。NAAD可用作研究烟酰胺腺嘌呤二核苷酸合成酶（NAD）的特异性和动力学的底物。此外，它还被用作研究Sir2类NAD+-依赖型脱乙酰酶代谢的辅底物。
Other Notes
β-NAD类似物
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hong Zhang et al.
Structure (London, England : 1993), 10(1), 69-79 (2002-02-14)
Nicotinamide/Nicotinate mononucleotide (NMN/NaMN) adenylyltransferase is an indispensable enzyme in both de novo biosynthesis and salvage of NAD+ and NADP+. In prokaryotes, it is absolutely required for cell survival, thus representing an attractive target for the development of new broad-spectrum antibacteria
Shanyun Lu et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 64(Pt 10), 893-898 (2008-10-22)
Nicotinic acid mononucleotide adenylyltransferase (NaMNAT; EC 2.7.7.18) is the penultimate enzyme in the biosynthesis of NAD(+) and catalyzes the adenylation of nicotinic acid mononucleotide (NaMN) by ATP to form nicotinic acid adenine dinucleotide (NaAD). This enzyme is regarded as a
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
Sasaki Y, et al.
The Journal of Neuroscience, 26(33), 8484-8491 (2006)
Anthony A Sauve et al.
Biochemistry, 42(31), 9249-9256 (2003-08-06)
Life span regulation and inhibition of gene silencing in yeast have been linked to nicotinamide effects on Sir2 enzymes. The Sir2 enzymes are NAD(+)-dependent protein deacetylases that influence gene expression by forming deacetylated proteins, nicotinamide and 2'-O-acetyl-ADPR. Nicotinamide is a
The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axonal degeneration
Essuman K, et al.
Neuron, 93(6), 1334-1343 (2017)
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