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Merck
CN

N4766

N-亚硝基-N-甲基脲

Bulk package

别名:

MNU, N-甲基-N-亚硝基脲

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关于此项目

经验公式(希尔记法):
C2H5N3O2
化学文摘社编号:
分子量:
103.08
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
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表单

solid

包含

aqueous acetic acid as stabilizer

储存温度

2-8°C

SMILES字符串

CN(N=O)C(N)=O

InChI

1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)

InChI key

ZRKWMRDKSOPRRS-UHFFFAOYSA-N

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生化/生理作用

一种在许多动物物种中具有致癌性的DNA烷基化剂。 尽管MNU可以在大多数器官中诱发良性和恶性肿瘤,但它最常用于模拟乳腺肿瘤的发生和发展。

包装

Weight on dry basis.

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B

储存分类代码

4.1B - Flammable solid hazardous materials

WGK

WGK 1

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Yuan-Yuan Chen et al.
Experimental eye research, 121, 102-113 (2014-02-11)
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was
Dawne N Shelton et al.
PloS one, 7(7), e40312-e40312 (2012-07-14)
Endometrial carcinoma is the most common gynecologic cancer, yet the mechanisms underlying this disease process are poorly understood. We hypothesized that Lef1 is required for endometrial gland formation within the uterus and is overexpressed in endometrial cancer. Using Lef1 knockout

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