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Merck
CN

N4779

5-硝基-2-(3-苯基丙基氨基)苯甲酸

≥98%, chloride channel blocker, solid

别名:

NPPB

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关于此项目

经验公式(希尔记法):
C16H16N2O4
化学文摘社编号:
分子量:
300.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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产品名称

5-硝基-2-(3-苯基丙基氨基)苯甲酸, ≥98%

质量水平

方案

≥98%

表单

solid

溶解性

ethanol: 3 mg/mL
DMSO: 37 mg/mL
H2O: insoluble

储存温度

−20°C

SMILES字符串

OC(=O)c1cc(ccc1NCCCc2ccccc2)[N+]([O-])=O

InChI

1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)

InChI key

WBSMIPAMAXNXFS-UHFFFAOYSA-N

生化/生理作用

强效氯离子通道阻滞剂。

特点和优势

该化合物在受体分类和信号转导手册的氯化物通道页面上有重点介绍。想要浏览手册的其他页面, 请单击此处

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Agnieszka Dyrda et al.
PloS one, 5(2), e9447-e9447 (2010-03-03)
The mechanical, rheological and shape properties of red blood cells are determined by their cortical cytoskeleton, evolutionarily optimized to provide the dynamic deformability required for flow through capillaries much narrower than the cell's diameter. The shear stress induced by such
Michael R Bristow et al.
JACC. Basic to translational science, 5(9), 871-883 (2020-08-25)
Using serial analysis of myocardial gene expression employing endomyocardial biopsy starting material in a dilated cardiomyopathy cohort, we show that mRNA expression of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) cardiac myocyte receptor ACE2 is up-regulated with remodeling and with reverse
Alwin Scharstuhl et al.
PloS one, 4(8), e6688-e6688 (2009-08-21)
We previously identified curcumin as a potent inducer of fibroblast apoptosis, which could be used to treat hypertrophic scar formation. Here we investigated the underlying mechanism of this process. Curcumin-induced apoptosis could not be blocked by caspase-inhibitors and we could
Anaïs Merckx et al.
PLoS pathogens, 4(2), e19-e19 (2008-02-06)
Malaria symptoms occur during Plasmodium falciparum development into red blood cells. During this process, the parasites make substantial modifications to the host cell in order to facilitate nutrient uptake and aid in parasite metabolism. One significant alteration that is required
Tae Sik Sung et al.
The Journal of physiology, 596(9), 1549-1574 (2018-02-13)
Enteric neurotransmission is essential for gastrointestinal (GI) motility, although the cells and conductances responsible for post-junctional responses are controversial. The calcium-activated chloride conductance (CaCC), anoctamin-1 (Ano1), was expressed by intramuscular interstitial cells of Cajal (ICC-IM) in proximal stomach and not

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