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Merck
CN

N5131

烟酰胺鸟嘌呤二核苷酸 钠盐

phospodiesterase and ADP-ribosyl cyclase substrate

别名:

3-(Aminocarbonyl)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-Amino-6-Oxo-1,6-Dihydro-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl]methoxy}(Hydroxy)phosphoryl]oxy} (Hydroxy)phosphoryl]ox, NGD

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关于此项目

经验公式（希尔记法）:
C21H28N7O15P2
化学文摘社编号:
5624-35-1
分子量:
680.43
NACRES:
NA.51
PubChem Substance ID:
24897721
UNSPSC Code:
41106305
MDL number:
MFCD00079505
Form:
powder
Assay:
≥-96%
Solubility:
H2O: soluble-50 mg/mL, clear, almost colorless to slightly yellow
Biological source:
yeast

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InChI

1S/C21H28N7O15P2/c22-16(33)8-2-1-3-27(4-8)19-14(31)12(29)9(41-19)5-39-44(35,36)43-45(37,38)40-6-10-13(30)15(32)20(42-10)28-7-24-11-17(28)25-21(23)26-18(11)34/h1-4,7,9-10,12-15,19-20,29-32H,5-6H2,(H2,22,33)(H,35,36)(H,37,38)(H3,23,25,26,34)

SMILES string

NC(=O)C1=CC=C[N](=C1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5C(=O)N=C(N)Nc45)C(O)C2O

InChI key

WWXCUPZEUROLRY-UHFFFAOYSA-N

biological source

yeast

assay

≥-96%

form

powder

solubility

H2O: soluble-50 mg/mL, clear, almost colorless to slightly yellow

storage temp.

−20°C

Quality Level

200

Application

烟酰胺鸟嘌呤二核苷酸 (NGD +) 可作为特异性蛇 竹叶青蛇 蛇毒磷酯酶的首选底物和研究 ADP-核糖环化酶 (s) 的特异性和动力学的底物。
烟酰胺鸟嘌呤二核苷酸钠盐已被用作测量分化 38 (CD38) 酶簇环化酶活性的底物。也用作荧光测定法测定 CD38/ADP-核糖 (ADPR) 活性的底物。

Biochem/physiol Actions

烟酰胺鸟嘌呤二核苷酸钠盐用于测定 ADP-核糖环化酶家族中生成环-ADP-核糖 (cADPR) 的蛋白质的活性。

Other Notes

β 类似物-NAD

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000464690
0000464689
0000464689
0000464690
0000461573

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Lili Peng et al.
Biochimie, 93(9), 1601-1609 (2011-06-15)
The phosphodiesterases (PDEs) are a superfamily of enzymes that have multiple roles in extracellular nucleotide metabolism and in the regulation of nucleotide-based intercellular signaling. Here we describe for the first time the isolation and partial characterization of a novel phosphodiesterase
Large-scale purification of Aplysia ADP-ribosylcyclase and measurement of its activity by fluorimetric assay.
H C Lee et al.
Methods in enzymology, 280, 331-340 (1997-01-01)
C Munshi et al.
Biochimica et biophysica acta, 1388(2), 428-436 (1998-12-22)
ADP-ribosyl cyclase is a multi-functional enzyme that catalyzes the formation of two Ca2+ signaling molecules, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). X-ray crystallography of three different crystal forms shows that it is a non-covalent dimer. Chemical
Measuring CD38 Hydrolase and Cyclase Activities: 1, N6-Ethenonicotinamide Adenine Dinucleotide (varepsilon-NAD) and Nicotinamide Guanine Dinucleotide (NGD) Fluorescence-based Methods
de Oliveira GC, et al.
Bio-protocol, 8(14) (2018)
Leanne T Breen et al.
American journal of physiology. Renal physiology, 290(2), F486-F495 (2005-09-29)
Endogenous nucleotides with extracellular functions may be involved in the complex neural control of human urinary bladder (HUB). Using HPLC techniques with fluorescence detection, we observed that in addition to ATP and its metabolites ADP, AMP and adenosine, electrical field
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