N5163
Anti-NOTCH4 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-INT3, Anti-Notch homolog 4 (Drosophila)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~230 kDa, antigen ~80 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:200, western blot: 1:500-1:1,000
UniProt accession no.
application(s)
research pathology
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NOTCH4(4855)
mouse ... Notch4(18132)
rat ... Notch4(406162)
General description
NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.
Immunogen
synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.
Biochem/physiol Actions
NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
AKT and 14-3-3 regulate Notch4 nuclear localization.
Ramakrishnan G
Scientific Reports, 5, 8782-8782 (2015)
NOTCH4 is a potential therapeutic target for triple-negative breast cancer.
Nagamatsu I
Anticancer Research, 34(1), 69-80 (2014)
Genetic variability testing of neurodevelopmental genes in schizophrenic patients.
Terzic T
Journal of Molecular Neuroscience, 56(1), 205-211 (2015)
Cuijuan Qian et al.
Molecular and cellular biochemistry, 401(1-2), 165-174 (2014-12-17)
Gastric cancer (GC) is one of the most common cancers and lethal malignancies in the world. Discovering novel biomarkers that correlate with GC may provide opportunities to reduce the severity of GC. As one of Notch receptor family members in
Ana Mafalda Baptista Tadeu et al.
Development (Cambridge, England), 140(18), 3777-3786 (2013-08-09)
The development of the mature epidermis requires a coordinated sequence of signaling events and transcriptional changes to specify surface ectodermal progenitor cells to the keratinocyte lineage. The initial events that specify epidermal keratinocytes from ectodermal progenitor cells are not well
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