Anti-NOTCH4 antibody produced in rabbit

NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.

synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.

NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.

solution in phosphate buffered saline, containing 0.02% sodium azide.

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