N5163
Anti-NOTCH4 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-INT3, Anti-Notch homolog 4 (Drosophila)
产品名称
Anti-NOTCH4 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~230 kDa
antigen ~80 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt accession no.
application(s)
research pathology
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NOTCH4(4855)
mouse ... Notch4(18132)
rat ... Notch4(406162)
Biochem/physiol Actions
NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.
Immunogen
synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Genetic variability testing of neurodevelopmental genes in schizophrenic patients.
Terzic T
Journal of Molecular Neuroscience, 56(1), 205-211 (2015)
AKT and 14-3-3 regulate Notch4 nuclear localization.
Ramakrishnan G
Scientific Reports, 5, 8782-8782 (2015)
NOTCH4 is a potential therapeutic target for triple-negative breast cancer.
Nagamatsu I
Anticancer Research, 34(1), 69-80 (2014)
Cuijuan Qian et al.
Molecular and cellular biochemistry, 401(1-2), 165-174 (2014-12-17)
Gastric cancer (GC) is one of the most common cancers and lethal malignancies in the world. Discovering novel biomarkers that correlate with GC may provide opportunities to reduce the severity of GC. As one of Notch receptor family members in
Fernanda Silva et al.
Oncology letters, 12(4), 2686-2691 (2016-10-05)
Epithelial ovarian cancer is the most lethal gynecologic malignancy, despite advances in treatment. The most common histological type, high-grade ovarian serous carcinoma (OSC) is usually diagnosed at an advanced stage, and although these types of tumors frequently respond to surgery
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