N5260
(-)-尼古丁 酒石酸氢盐
≥98% (TLC), powder
别名:
(-)-1-甲基-2-(3-吡啶基)吡咯烷 (+)-酒石酸氢盐
方案
≥98% (TLC)
表单
powder
颜色
white to off-white
溶解性
H2O: 50 mg/mL
SMILES字符串
CN1CCC[C@H]1C2=CC=CN=C2.C
InChI
1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1
InChI key
RYYKFQGHMYGLEL-PPHPATTJSA-N
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生化/生理作用
原型烟酸乙酰胆碱受体激动剂;天然异构体。
警示用语：
Danger
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 2
闪点(°F)
289.8 °F
闪点(°C)
143.2 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
Jhodie R Duncan et al.
Journal of applied physiology (Bethesda, Md. : 1985), 107(5), 1579-1590 (2009-09-05)
During pregnancy, exposure to nicotine and other compounds in cigarette smoke increases the risk of the sudden infant death syndrome (SIDS) two- to fivefold. Serotonergic (5-HT) abnormalities are found, in infants who die of SIDS, in regions of the medulla
Song Xue et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 22(2), 172-179 (2018-11-20)
Tobacco is highly addictive, and after the development of dependence, it is difficult to quit smoking. Therefore, it is important to understand the factors that play a role in the initiation of smoking. The rewarding effects of nicotine play a
Adam J Prus et al.
Pharmacology, biochemistry, and behavior, 91(1), 150-154 (2008-07-23)
The Lewis (LEW) strain of rat appears more sensitive to nicotine than other strains in self-administration, conditioned place preference, and drug discrimination behavioral studies. The present study sought to further evaluate the behavioral effects of chronic nicotine treatment in the
Jonathan D Raybuck et al.
Behavioral neuroscience, 122(5), 1166-1171 (2008-10-01)
Varenicline, a partial agonist for a4ss2 nicotinic acetylcholine receptors (nAChRs) and full agonist for a7 nAChRs, has been approved for the treatment of smoking cessation. Although recent clinical trials support the efficacy of varenicline for managing global nicotine withdrawal symptoms
Philippe Klee et al.
Endocrinology, 157(10), 3800-3808 (2016-07-30)
Type 1 diabetes (T1DM) results from destruction of most insulin-secreting pancreatic β-cells. The persistence of β-cells decades after the onset of the disease indicates that the resistance of individual cells to the autoimmune insult is heterogeneous and might depend on
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