N5501
Nω-硝基-L-精氨酸
synthetic, ≥98% (TLC), Nitric oxide synthase inhibitor, powder
别名:
L-NNA, N5-（硝酰胺基）-L-2,5-二氨基戊酸, NG-NO2-L-精氨酸
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关于此项目
经验公式（希尔记法）:
C6H13N5O4
化学文摘社编号:
分子量:
219.20
Beilstein:
1728914
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Nω-硝基-L-精氨酸, ≥98% (TLC)
生物来源
synthetic
质量水平
方案
≥98% (TLC)
表单
powder
mp
257 °C
溶解性
1 M HCl: 50 mg/mL, clear, colorless to faintly yellow
SMILES字符串
N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O
InChI
1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
InChI key
MRAUNPAHJZDYCK-BYPYZUCNSA-N
基因信息
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
mouse ... Nos2(18126)
rat ... Grin2a(24409), Nos1(24598)
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应用
Nω-硝基-L-精氨酸已被用于：
- 作为一氧化氮合成酶 (NOS) 抑制剂，用于测量细胞色素C还原检测中一氧化氮（NO）衍生物的释放量
- 收缩研究用纤维束的预处理
- 作为 NOS 抑制剂表征云南红豆杉 细胞中NO的生成
- 作为神经元一氧化氮合成酶 (nNOS) 的不可逆抑制剂对浮囊制剂作进行预先温育处理
生化/生理作用
Nω-硝基-L-精氨酸/L-NNA 有助于降低高碳酸血症导致的皮质充血和大脑 cGMP的水平。
组成型一氧化氮合酶（nNOS）的不可逆抑制剂和诱导型一氧化氮合酶（iNOS）的可逆抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Cyclic GMP is a second messenger by which nitric oxide inhibits diaphragm contraction
Abraham R Z, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 119(1), 177-183 (1998)
Nitric oxide modulates excitation-contraction coupling in the diaphragm
Reid M B, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 119(1), 211-218 (1998)
L-NNA decreases cortical hyperemia and brain cGMP levels following CO2 inhalation in Sprague-Dawley rats
Irikura K, et al.
The American Journal of Physiology, 267(2), H837-H843 (1994)
Helena Janols et al.
Journal of leukocyte biology, 96(5), 685-693 (2014-06-15)
The causative microorganisms dictate the type of MDSC generated in sepsis patients, and a large proportion of PMN-MDSCs in gram-positive sepsis includes immunosuppressive myeloid blasts. MDSCs constitute a heterogeneous population of immature myeloid cells that potently suppress immune responses. They
K D Keef et al.
The Journal of physiology, 591(6), 1489-1506 (2013-01-23)
There is evidence that vasoactive intestinal polypeptide (VIP) participates in inhibitory neuromuscular transmission (NMT) in the internal anal sphincter (IAS). However, specific details concerning VIP-ergic NMT are limited, largely because of difficulties in selectively blocking other inhibitory neural pathways. The
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