N5501
Nω-硝基-L-精氨酸
synthetic, ≥98% (TLC), Nitric oxide synthase inhibitor, powder
别名:
L-NNA, N5-（硝酰胺基）-L-2,5-二氨基戊酸, NG-NO2-L-精氨酸
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关于此项目
经验公式（希尔记法）:
C6H13N5O4
化学文摘社编号:
分子量:
219.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
218-418-9
MDL number:
Beilstein/REAXYS Number:
1728914
产品名称
Nω-硝基-L-精氨酸, ≥98% (TLC)
SMILES string
N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O
InChI key
MRAUNPAHJZDYCK-BYPYZUCNSA-N
InChI
1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
biological source
synthetic
assay
≥98% (TLC)
form
powder
mp
257 °C
solubility
1 M HCl: 50 mg/mL, clear, colorless to faintly yellow
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
mouse ... Nos2(18126)
rat ... Grin2a(24409), Nos1(24598)
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Application
Nω-硝基-L-精氨酸已被用于：
- 作为一氧化氮合成酶 (NOS) 抑制剂，用于测量细胞色素C还原检测中一氧化氮（NO）衍生物的释放量
- 收缩研究用纤维束的预处理
- 作为 NOS 抑制剂表征云南红豆杉 细胞中NO的生成
- 作为神经元一氧化氮合成酶 (nNOS) 的不可逆抑制剂对浮囊制剂作进行预先温育处理
Biochem/physiol Actions
Nω-硝基-L-精氨酸/L-NNA 有助于降低高碳酸血症导致的皮质充血和大脑 cGMP的水平。
组成型一氧化氮合酶（nNOS）的不可逆抑制剂和诱导型一氧化氮合酶（iNOS）的可逆抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Nitric oxide modulates excitation-contraction coupling in the diaphragm
Reid M B, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 119(1), 211-218 (1998)
Ai-Ling Lin et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(9), 1412-1421 (2013-06-27)
Vascular pathology is a major feature of Alzheimer's disease (AD) and other dementias. We recently showed that chronic administration of the target-of-rapamycin (TOR) inhibitor rapamycin, which extends lifespan and delays aging, halts the progression of AD-like disease in transgenic human
Involvement of nitric oxide in oxidative burst, phenylalanine ammonia-lyase activation and Taxol production induced by low-energy ultrasound in Taxus yunnanensis cell suspension cultures.
Wang JW
Nitric Oxide, 15(4), 351-358 (2006)
Comp Biochem Physiol A Mol Integr Physiol
Schwerte T, et al.
The Journal of Experimental Biology, 202(8), 1005-1013 (1999)
Ming-Guo Feng et al.
American journal of physiology. Renal physiology, 303(5), F775-F782 (2012-06-08)
Nebivolol is a β(1)-adrenergic blocker that also elicits renal vasodilation and increases the glomerular filtration rate (GFR). However, its direct actions on the renal microvasculature and vasodilator mechanism have not been established. We used the in vitro blood-perfused juxtamedullary nephron
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