Merck
CN
所有图片(5)

文件

N5751

Sigma-Aldrich

Nω-硝基-L-精氨酸甲酯 盐酸盐

≥97% (TLC), powder

登录查看公司和协议定价
所有图片(5)
别名:
L-NAME 盐酸盐
经验公式（希尔记法）:
C7H15N5O4 · HCl
CAS号:
51298-62-5
分子量:
269.69
Beilstein:
3744166
EC 号:
257-116-1
MDL编号:
MFCD00039052
PubChem化学物质编号:
24278011
NACRES:
NA.77

生物来源

synthetic

质量水平

200

检测方案

≥97% (TLC)

形式

powder

颜色

white to off-white

mp

132 °C

溶解性

H2O: 50 mg/mL

储存温度

−20°C

SMILES字符串

Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O

InChI

1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1

InChI key

QBNXAGZYLSRPJK-JEDNCBNOSA-N

正在寻找类似产品? Visit 产品对比指南

相关类别

应用

Nω-硝基-L-精氨酸甲酯盐酸盐已被用于：
  • 研究脑源性神经营养因子对大鼠皮层神经元神经毒性的影响
  • 研究其对远红外（FIR）增强大鼠皮肤微循环的影响
  • 研究其对瘦素诱导的小鼠肌细胞和脂肪细胞中肌肉因子III型纤连蛋白结构域包含蛋白5/鸢尾素调节的影响
  • 研究其对大鼠下丘脑室旁核和视上核细胞内精氨酸加压素和神经元型一氧化氮合酶mRNA水平的影响

生化/生理作用

抑制NO产生的精氨酸类似物。它对血管系统有多重作用。抑制乙酰胆碱引起的舒张，并引起动脉血压升高。 用于预处理小鼠主动脉环制剂时，可取消卵磷脂化超氧化物歧化酶诱导的血管舒张作用。 诱导白细胞粘附，增加微血管液以及蛋白质通量和渗透性。 它也被用于许多学习和记忆的相关研究。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

为方便起见，与您过往购买产品相关的文件已保存在文档库中。

访问文档库

难以找到您所需的产品或批次号码？

在网站页面上，产品编号会附带包装尺寸/数量一起显示（例如：T1503-25G）。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

遇到问题？欢迎随时联系我们技术服务 寻求帮助

批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。

  • 如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。

  • 如果您查询到的批号含有填充代码（例如 STBB0728K9），请输入去除填充代码K9的批号：STBB0728。

未找到您寻找的产品？

部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solution stability of Product N5751, L-NAME hydrochloride?

    Although we do not perform solution stability studies, one literature reference recommends keeping solutions on ice during the course of one day.

  6. How do I sterilize a prepared solution of Product N5751, L-NAME hydrochloride?

    Solutions of this product may be sterile-filtered.

  7. Is Product N5751, L-NAME hydrochloride, an inhibitor of Nitric Oxide Synthase (NOS)?

    L-NAME was described as a reversible, non-specific inhibitor of nitric oxide synthase by Khavandgar. S. et al., Pharmacol. Biochem. Behav., 74, 795 (2003).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

P Kubes et al.
The American journal of physiology, 262(2 Pt 2), H611-H615 (1992-02-01)
We recently demonstrated that inhibitors of nitric oxide (NO) production cause a dramatic increase in leukocyte adherence and emigration in postcapillary venules. The objective of this study was to assess whether inhibition of NO production leads to vascular protein leakage
L B Zou et al.
Neuropharmacology, 37(3), 323-330 (1998-07-29)
We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained
Anne-Clémence Vion et al.
Circulation research, 112(10), 1323-1333 (2013-03-29)
Endothelial activation and apoptosis release membrane-shed microparticles (EMP) that emerge as important biological effectors. Because laminar shear stress (SS) is a major physiological regulator of endothelial survival, we tested the hypothesis that SS regulates EMP release. EMP levels were quantified
Biological effect of far-infrared therapy on increasing skin microcirculation in rats
Yu SY, et al.
Photodermatology, Photoimmunology & Photomedicine, 22(2), 78-86 (2006)
Amanda E Boe et al.
Circulation, 128(21), 2318-2324 (2013-10-05)
Long-term inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-l-arginine methyl ester (L-NAME) has been shown to induce senescence in vitro and systemic hypertension and arteriosclerosis in vivo. We previously reported that plasminogen activator inhibitor-1 (PAI-1)-deficient mice (PAI-1(-/-))
查看所有相关文献

相关内容

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门