N6252
去甲哈尔满
≥98% (TLC), crystalline, monoamine oxidase inhibitor
别名:
β-咔啉, 9H-吡啶并[3,4-b]吲哚
Product Name
去甲哈尔满, crystalline
表单
crystalline
质量水平
颜色
light yellow
储存温度
2-8°C
SMILES字符串
c1ccc2c(c1)[nH]c3cnccc23
InChI
1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
InChI key
AIFRHYZBTHREPW-UHFFFAOYSA-N
基因信息
human ... IKBKB(3551)
rat ... Gabra2(29706)
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一般描述
Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.
应用
Norharmane has been used:
- as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
- as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
- as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)
生化/生理作用
吲哚胺 2,3-双加氧酶 (IDO) 的抑制剂。
Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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