N6514
神经氨酸酶 来源于霍乱弧菌
Type II, buffered aqueous solution, 8-24 units/mg protein (Lowry, using NAN-lactose)
别名:
受体破坏酶, 唾液酸酶, 神经氨酸苷酶
生物来源
Vibrio cholerae
质量水平
类型
Type II
表单
buffered aqueous solution
比活
8-24 units/mg protein (Lowry, using NAN-lactose)
异质活性
Protease and NAN-aldolase, present
储存温度
2-8°C
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一般描述
神经氨酸酶是一种促进流感病毒从感染细胞释放并促进病毒传播的水解酶。
量热法研究表明，神经氨酸酶中心催化结构域侧翼的两个凝集素样结构域可作为含唾液酸底物的识别和结合位点。
应用
来自霍乱弧菌的神经氨酸酶已被用于一项描述五步纯化方法的研究中。 它还被用于一项探究白血病L1210肿瘤细胞修饰的研究中。
神经氨酸酶被用作糖缀合物分布和底物特异性研究的细胞表面探针。
外形
含有0.15 M 氯化钠及及4 mM 叠氮化钠并经0.2 μm滤器过滤的pH 5.5 50 M 醋酸钠中的溶液。
制备说明
通过亲和色谱度我们的III类进行进一步纯化。
分析说明
不含防腐剂。
其他说明
除特殊规定，在37 °C pH 5.0条件下，一个单位可在每分钟内从NAN-乳糖或牛颌下粘蛋白中释放将1.0 μ摩尔的N-乙酰神经氨酸。价格是基于使用NAN-乳糖作为底物的单位。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Julia Moh-Klaren et al.
Transfusion, 57(11), 2571-2577 (2017-06-24)
Red blood cell (RBC) Thomsen-Friedenreich antigen exposure (T activation) in infants with necrotizing enterocolitis (NEC) has occasionally been associated with posttransfusional intravascular hemolysis thought to be due to anti-T antibodies in the donor plasma. We describe an infant with NEC
Ibrahim Moustafa et al.
The Journal of biological chemistry, 279(39), 40819-40826 (2004-07-01)
Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for cholera toxin. We previously showed that the structure of VCNA is composed of
Hirokazu Kai et al.
Bioorganic & medicinal chemistry, 20(8), 2739-2746 (2012-03-14)
A selective and potent inhibitor of neuraminidases, a hydrolase that is responsible for processing sialylated glycoconjugates, is a promising drug candidate for various infective diseases. The current study demonstrates that the use of an aglycone-focused library of 2-difluoromethylphenyl α-sialosides is
Increase of leukemia L1210 immunogenicity by Vibrio cholerae neuraminidase treatment.
J G Bekesi et al.
Cancer research, 31(12), 2130-2132 (1971-12-01)
Paul Clark et al.
Viruses, 12(10) (2020-10-24)
Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating polyomavirus entry are poorly understood. Through genetic knockdown approaches, we
商品
Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.
实验方案
Enzymatic Assay of Neuraminidase applies to products that have a specification for neuraminidase content by enzymatic determination.
在测定神经氨酸酶活性时，使用了一种以N-乙酰新胺酸为酶底物的比色法进行测定。神经氨酸酶是一种可促进流感病毒从感染细胞中释放的水解酶。
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