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Merck
CN

N6514

神经氨酸酶 来源于霍乱弧菌

Type II, buffered aqueous solution, 8-24 units/mg protein (Lowry, using NAN-lactose)

别名:

受体破坏酶, 唾液酸酶, 神经氨酸苷酶

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关于此项目

化学文摘社编号:
9001-67-6
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-624-6
MDL number:
MFCD00131711
EC 号:
3.2.1.18 (BRENDA, IUBMB)
Specific activity:
8-24 units/mg protein (Lowry, using NAN-lactose)
Biological source:
Vibrio cholerae

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产品名称

神经氨酸酶 来源于霍乱弧菌, Type II, buffered aqueous solution, 8-24 units/mg protein (Lowry, using NAN-lactose)

biological source

Vibrio cholerae

type

Type II

form

buffered aqueous solution

specific activity

8-24 units/mg protein (Lowry, using NAN-lactose)

foreign activity

Protease and NAN-aldolase, present

storage temp.

2-8°C

Quality Level

200

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Analysis Note

不含防腐剂。

Application

来自霍乱弧菌的神经氨酸酶已被用于一项描述五步纯化方法的研究中。 它还被用于一项探究白血病L1210肿瘤细胞修饰的研究中。
神经氨酸酶被用作糖缀合物分布和底物特异性研究的细胞表面探针。

General description

神经氨酸酶是一种促进流感病毒从感染细胞释放并促进病毒传播的水解酶。
量热法研究表明，神经氨酸酶中心催化结构域侧翼的两个凝集素样结构域可作为含唾液酸底物的识别和结合位点。

Other Notes

除特殊规定，在37 °C pH 5.0条件下，一个单位可在每分钟内从NAN-乳糖或牛颌下粘蛋白中释放将1.0 μ摩尔的N-乙酰神经氨酸。价格是基于使用NAN-乳糖作为底物的单位。

Physical form

含有0.15 M 氯化钠及及4 mM 叠氮化钠并经0.2 μm滤器过滤的pH 5.5 50 M 醋酸钠中的溶液。

Preparation Note

通过亲和色谱度我们的III类进行进一步纯化。

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000496094
0000496094
0000345920
0000345920
0000288201

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Ibrahim Moustafa et al.
The Journal of biological chemistry, 279(39), 40819-40826 (2004-07-01)
Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for cholera toxin. We previously showed that the structure of VCNA is composed of
Julia Moh-Klaren et al.
Transfusion, 57(11), 2571-2577 (2017-06-24)
Red blood cell (RBC) Thomsen-Friedenreich antigen exposure (T activation) in infants with necrotizing enterocolitis (NEC) has occasionally been associated with posttransfusional intravascular hemolysis thought to be due to anti-T antibodies in the donor plasma. We describe an infant with NEC
S Crennell et al.
Structure (London, England : 1993), 2(6), 535-544 (1994-06-15)
Vibrio cholerae neuraminidase is part of a mucinase complex which may function in pathogenesis by degrading the mucin layer of the gastrointestinal tract. The neuraminidase, which has been the target of extensive inhibitor studies, plays a subtle role in the
Nicolas Burin des Roziers et al.
Transfusion, 55(6 Pt 2), 1563-1571 (2015-01-06)
Pneumococcal hemolytic uremic syndrome (P-HUS) is a rare but severe complication of invasive pneumococcal disease (IPD) in young children. Consensual biologic diagnosis criteria are currently lacking. A prospective study was conducted on 10 children with culture-confirmed IPD. Five presented with
Hirokazu Kai et al.
Bioorganic & medicinal chemistry, 20(8), 2739-2746 (2012-03-14)
A selective and potent inhibitor of neuraminidases, a hydrolase that is responsible for processing sialylated glycoconjugates, is a promising drug candidate for various infective diseases. The current study demonstrates that the use of an aglycone-focused library of 2-difluoromethylphenyl α-sialosides is
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Sialic Acid

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实验方案

Enzymatic Assay of Neuraminidase

Enzymatic Assay of Neuraminidase applies to products that have a specification for neuraminidase content by enzymatic determination.

神经氨酸酶酶促检测方法

在测定神经氨酸酶活性时，使用了一种以N-乙酰新胺酸为酶底物的比色法进行测定。神经氨酸酶是一种可促进流感病毒从感染细胞中释放的水解酶。

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