生物来源
mouse
质量水平
重组
expressed in NSO cells
方案
>95% (SDS-PAGE)
表单
lyophilized powder
分子量
55-60 kDa by SDS-PAGE (reducing)
calculated mol wt 50 kDa
包装
pkg of 50 μg
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Nog(18121)
生化/生理作用
Binds and blocks the acitivity of bone morphogenetic proteins (BMPs).
Binds and blocks the acitivity of bone morphogenetic proteins (BMPs). Mature mouse noggin shares 99% and 83% sequence identity with human and Xenopus noggin, respectively.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
分析说明
The biological activity is measured by its ability to inhibit recombinant human BMP-4 induced alkaline phosphatase activity in ATDC5 cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues.
Laurila R
International Journal of Clinical and Experimental Pathology (2013)
Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.
Wu XB
The Journal of Clinical Investigation (2003)
D A Lim et al.
Neuron, 28(3), 713-726 (2001-02-13)
Large numbers of new neurons are born continuously in the adult subventricular zone (SVZ). The molecular niche of SVZ stem cells is poorly understood. Here, we show that the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells
Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding.
Marcelino J
Proceedings of the National Academy of Sciences of the USA (2001)
A H Reddi
Arthritis research, 3(1), 1-5 (2001-02-15)
This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis. BMPs are a family of growth and differentiation factors, and they act on mesenchymal cells to induce
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