跳转至内容
Merck
CN

N7143

尼日利亚菌素 钠盐

From Streptomyces hygroscopicus, ≥98% (TLC), Ionophore, powder

别名:

Helexin C, 抗生素K178, 抗生素X464, 聚醚A, 阿扎霉素M

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C40H67NaO11
化学文摘社编号:
28643-80-3
分子量:
746.94
NACRES:
NA.77
PubChem Substance ID:
24897813
UNSPSC Code:
12352200
MDL number:
MFCD00036825
Beilstein/REAXYS Number:
3892398

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

尼日利亚菌素 钠盐, ≥98% (TLC)

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1

SMILES string

[Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@]2([H])C[C@@H](OC)[C@@H](C)[C@]3(O2)O[C@@](C)(C[C@H]3C)[C@@]4([H])CC[C@](C)(O4)[C@]5([H])O[C@]([H])(C[C@@H]5C)[C@@]6([H])O[C@@](O)(CO)[C@H](C)C[C@@H]6C

InChI key

MOYOTUKECQMGHE-PDEFJWSRSA-M

biological source

Streptomyces hygroscopicus

assay

≥98% (TLC)

form

powder

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

300

正在寻找类似产品? 访问 产品对比指南

相关类别

Application

尼日利亚菌素钠盐已用于引起人巨噬细胞中的NLRP3炎性小体活化。还作为细菌毒素激发单核细胞分泌IL-1β。

Biochem/physiol Actions

破坏膜电位并刺激线粒体中 ATPase 活性的聚醚离子载体。
破坏膜电位并刺激线粒体中 ATPase 活性的聚醚离子载体。离子选择性为 K+> Rb+≥ Cs+>> Na+。

General description

化学结构：聚醚
尼日利亚菌素是一种聚醚类离子载体，可用作跨线粒体膜的离子载体。它催化K+和H+的整体电中性交换(1)，并用作钾离子外排的激活剂。 可经由不依赖炎性小体的NLRP3蛋白(NOD-, LRR- and pyrin domain-containing protein 3)特异性机制增强杀菌作用。尼日利亚菌素是由多个氧杂环和一个羟基组成的线性分子。在膜中连接成环，形成类似缬氨霉素的结构。尼日利亚菌素因失去一个质子而与阳离子结合后形成中性复合物，成为跨膜扩散的移动载体。尼日利亚菌素的质子化非复合物形式同样具有移动性。

Other Notes

作为离子选择电极 - 一种高效的 K+ 载体。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000485847
0000485847
0000485846
0000485846
0000480935

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Adesola C Olatunde et al.
PloS one, 13(5), e0196591-e0196591 (2018-05-11)
Dendritic cells (DC) are sentinels of the immune system, alerting and enlisting T cells to clear pathogenic threats. As such, numerous studies have demonstrated their effective uptake and proteolytic activities coupled with antigen processing and presentation functions. Yet, less is
H Parfenova et al.
The American journal of physiology, 277(4 Pt 1), C728-C738 (1999-10-12)
Nigericin decreases intracellular pH (pH(i)) and stimulates prostanoid (PG) synthesis in endothelial cells from cerebral microvessels of newborn pigs. Nigericin-induced PG production was abolished by protein tyrosine kinase (PTK) inhibitors and amplified by phorbol 12-myristate 13-acetate (PMA) or protein tyrosine
Nardhy Gomez-Lopez et al.
Biology of reproduction, 100(5), 1306-1318 (2019-01-01)
Sterile intra-amniotic inflammation is commonly observed in patients with spontaneous preterm labor, a syndrome that commonly precedes preterm birth, the leading cause of perinatal morbidity and mortality worldwide. However, the mechanisms leading to sterile intra-amniotic inflammation are poorly understood and
Saskia F Erttmann et al.
Nature communications, 10(1), 3493-3493 (2019-08-04)
Hydrogen peroxide (H2O2) has a major function in host-microbial interactions. Although most studies have focused on the endogenous H2O2 produced by immune cells to kill microbes, bacteria can also produce H2O2. How microbial H2O2 influences the dynamics of host-microbial interactions
Nina Raben et al.
Methods in enzymology, 453, 417-449 (2009-02-17)
Lysosomes are the final destination of the autophagic pathway. It is in the acidic milieu of the lysosomes that autophagic cargo is metabolized and recycled. One would expect that diseases with primary lysosomal defects would be among the first systems
查看所有相关文献

相关内容

Product Information Sheet - N7143

Product Information Sheet

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持