N7155
Anti-Nitric Oxide Synthase, Brain (251-270) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-bNOS
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 150-160 kDa
species reactivity
human, rat
technique(s)
microarray: suitable, western blot: 1:10,000 using rat brain extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NOS1(4842)
rat ... Nos1(24598)
General description
Nitric Oxide Synthase, Brain (NOS1) is mapped to human chromosome 12q24.22. The NOS isoform found in neurons is a 150 kDa protein. It is also termed as brain NOS (bNOS). Human bNOS and endothelial NOS (eNOS) share 52% amino acid identity, and rat and human bNOS share 93% amino acid identity.
Immunogen
synthetic peptide corresponding to nitric oxide synthase (NOS) of rat brain origin (bNOS, amino acids 251-270) conjugated to KLH. The immunogen sequence is highly conserved in human bNOS.
Application
Anti-Nitric Oxide Synthase, Brain (251-270) antibody produced in rabbit has been used in:
- double immunolabelling,
- immunofluorescence
- western blotting
Biochem/physiol Actions
Nitric Oxide Synthase, Brain (bNOS) is present also in skeletal muscle, where it is complexed with dystrophin and is absent in Duchenne muscular dystrophy (DMD). Neuronal and endothelial NOS are constitutively expressed and are dependent on Ca2+ calmodulin for nitric oxide (NO) production.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Expression of nitric oxide synthase in the retina of monocular deprivation amblyopia rats
Wang QM, et al.
European Review for Medical and Pharmacological Sciences, 22(7), 1879-1883 (2018)
nNOS-expressing neurons in the ventral tegmental area and substantia nigra pars compacta
Paul EJ, et al.
eNeuro, 5(5), 100-100 (2018)
A melon pulp concentrate rich in superoxide dismutase reduces stress proteins along the gastrointestinal tract of pigs
Lalles JP, et al.
Nutrition, 27(3), 358-363 (2011)
Endothelial and neuronal nitric oxide synthases are present in the suprachiasmatic nuclei of Syrian hamsters and rats
Caillol M, et al.
The European Journal of Neuroscience, 12(2), 649-661 (2000)
Therapeutic strategies to address neuronal nitric oxide synthase deficiency and the loss of nitric oxide bioavailability in Duchenne Muscular Dystrophy
Timpani CA, et al.
Orphanet Journal of Rare Diseases, 12(1), 100-100 (2017)
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持