N7261
去甲替林 盐酸盐
≥98% (HPLC), norepinephrine and serotonin inhibitor, powder
别名:
3-(10,11-二氢-5 H -二苯并[ a , d ] 环庚烯-5-亚基)- N -甲基-1-丙胺 盐酸盐, 去甲阿米替林 盐酸盐
产品名称
去甲替林 盐酸盐, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
ethanol: 100 mg/mL
H2O: soluble
创始人
Eli Lilly
SMILES字符串
Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
InChI key
SHAYBENGXDALFF-UHFFFAOYSA-N
基因信息
human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)
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生化/生理作用
与 5-羟色胺转运体 (K i = 161 nM) 相比,三环类抗抑郁药是去甲肾上腺素转运体 (K i = 3.4 nM) 的一种更强效的抑制剂。5-HT 2 5-羟色胺受体拮抗剂。
特点和优势
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面, 请单击此处。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Fabrice Gritti et al.
Journal of chromatography. A, 1282, 58-71 (2013-02-21)
The adsorption behaviors of a neutral (caffeine) and a positively charged compound (nortriptylinium) are investigated on two RPLC/hybrid stationary phases, eluted with a low ionic strength buffer (phosphate buffer, W(S)pH 2.63, I=10mM). The first phase, bridge ethylene hybrid (BEH), is
Rudolf Uher et al.
Depression and anxiety, 29(12), 1043-1049 (2012-08-31)
It has been suggested that clinician-rated scales and self-report questionnaires may be interchangeable in the measurement of depression severity, but it has not been tested whether clinically significant information is lost when assessment is restricted to either clinician-rated or self-report
Abdennasser Bardai et al.
European heart journal, 34(20), 1506-1516 (2013-02-22)
Non-cardiac drugs that impair cardiac repolarization (electrocardiographic QT prolongation) are associated with an increased sudden cardiac arrest (SCA) risk. Emerging evidence suggests that non-cardiac drugs that impair cardiac depolarization and excitability (electrocardiographic QRS prolongation) also increase the risk for SCA.
Robert A Power et al.
Journal of psychiatric research, 46(10), 1333-1338 (2012-07-10)
Most comparisons of the efficacy of antidepressants have relied on the assumption that missing data are randomly distributed. Dropout rates differ between drugs, suggesting this assumption may not hold true. This paper examines the effect of non-random dropout on a
Lindsay F Stead et al.
The Cochrane database of systematic reviews, 12, CD009670-CD009670 (2012-12-14)
Effective pharmacotherapies are available to help people who are trying to stop smoking, but quitting can still be difficult and providing higher levels of behavioural support may increase success rates further. To evaluate the effect of increasing the intensity of
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