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Merck
CN

N7510

尼卡地平 盐酸盐

≥98%, L-type voltage-dependent calcium channel blocker, powder

别名:

1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸甲基 2- [甲基(苯甲基)氨基] 乙酯 盐酸盐, YC-93

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关于此项目

经验公式(希尔记法):
C26H29N3O6 · HCl
化学文摘社编号:
分子量:
515.99
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
259-198-4
MDL number:
Assay:
≥98%
Form:
powder
Quality level:
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产品名称

尼卡地平 盐酸盐, powder, ≥98%

Quality Level

assay

≥98%

form

powder

color

yellow

solubility

DMSO: ~1 mg/mL, 0.1 M NaOH: insoluble, H2O: slightly soluble, methanol: soluble

originator

EKR Therapeutics

storage temp.

2-8°C

SMILES string

Cl[H].COC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCCN(C)Cc3ccccc3

InChI

1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H

InChI key

AIKVCUNQWYTVTO-UHFFFAOYSA-N

Gene Information

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Biochem/physiol Actions

阻断 L 型电压依赖性钙通道;抗高血压药。

Features and Benefits

该化合物由 EKR Therapeutics 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里

pictograms

Skull and crossbones

signalword

Danger

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

hcodes

Hazard Classifications

Acute Tox. 3 Oral


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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T J Hibberd et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 29(10), 1-12 (2017-04-19)
Relatively little is known about the electrical rhythmicity of the whole colon, where long neural pathways are preserved. Smooth muscle electrical activity was recorded extracellularly from the serosa of isolated flat-sheet preparations consisting of the whole mouse colon (n=31). Two
GoEun Han et al.
Frontiers in neuroscience, 16, 969712-969712 (2022-11-08)
Non-rapid eye movement (NREM) sleep is tightly homeostatically regulated and essential for survival. In the electroencephalogram (EEG), oscillations in the delta (0.5-4 Hz) range are prominent during NREM sleep. These delta oscillations are, to date, the best indicator for homeostatic
S Thellung et al.
Neurobiology of disease, 7(4), 299-309 (2000-08-31)
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrP(Sc). A synthetic peptide homologous to residues 106-126 of PrP (PrP106-126) was reported to maintain the neurodegenerative characteristics of
Avril Coghlan et al.
PLoS neglected tropical diseases, 17(9), e0011205-e0011205 (2023-09-05)
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be
T Matsuda et al.
General pharmacology, 33(2), 115-125 (1999-08-26)
The effects of nicardipine and bupivacaine on early afterdepolarizations (EADs) were investigated in rabbit sinoatrial (SA) nodes using the conventional microelectrode technique. In a nominally Ca2+ -free, Mg2+ -free solution, addition of 0.5 mM Sr2+ produced EADs following prolongation of

全球贸易项目编号

货号GTIN
N7510-5G04061832962283
N7510-10G04061832962276
N7510-1G04061835506514

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