N7537
NSC 663284
≥98% (HPLC), solid
别名:
6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
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关于此项目
经验公式（希尔记法）:
C15H16ClN3O3
化学文摘社编号:
分子量:
321.76
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
NSC 663284, ≥98% (HPLC), solid
InChI key
BMKPVDQDJQWBPD-UHFFFAOYSA-N
SMILES string
ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
InChI
1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
red
solubility
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... CDC25B(994), DUSP3(1845), PTPN1(5770)
Biochem/physiol Actions
NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
Application
NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
470.1 °F
flash_point_c
243.4 °C
ppe
dust mask type N95 (US), Eyeshields, Gloves
Inhibition of DUSP13B Activity by NSC 663284
Lee I S, et al.
Bulletin of the Korean Chemical Society,, 33(10), 3505-3507 (2012)
Utility of resazurin, horseradish peroxidase, and NMR assays to identify redox-related false-positive behavior in high-throughput screens
Tarnowski M, et al.
Assay and Drug Development Technologies, 16(3), 171-191 (2018)
Kizuna is a novel mitotic substrate for CDC25B phosphatase
Thomas Y, et al.
Cell Cycle, 13(24), 3867-3877 (2014)
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