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N7537

NSC 663284

Name: NSC 663284
Brand: SIGMA

≥98% (HPLC), solid

别名:

6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

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About This Item

经验公式（希尔记法）:

C₁₅H₁₆ClN₃O₃

CAS Number:

383907-43-5

分子量:

321.76

MDL编号:

MFCD08276924

UNSPSC代码:

12352200

PubChem化学物质编号:

24724556

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

solid

储存条件

protect from light

颜色

red

溶解性

DMSO: ≥10 mg/mL
H₂O: insoluble

储存温度

2-8°C

SMILES字符串

ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O

InChI

1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2

InChI key

BMKPVDQDJQWBPD-UHFFFAOYSA-N

基因信息

human ... CDC25B(994), DUSP3(1845), PTPN1(5770)

应用

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

生化/生理作用

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

470.1 °F

闪点(°C)

243.4 °C

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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