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N7764

烟酸单核苷酸

Name: 烟酸单核苷酸
Brand: SIGMA

别名:

Nicotinate mononucleotide

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关于此项目

经验公式（希尔记法）:

C₁₁H₁₄NO₉P

化学文摘社编号:

321-02-8

分子量:

335.20

NACRES:

NA.79

PubChem Substance ID:

24897839

UNSPSC Code:

12352106

MDL number:

MFCD00070358

Assay:

≥98.0% (HPLC)

Biological source:

animal

Form:

powder

Storage temp.:

−20°C

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biological source

animal

Quality Level

200

assay

≥98.0% (HPLC)

form

powder

technique(s)

HPLC: suitable

color

white

storage temp.

−20°C

SMILES string

OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O

InChI

1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)

InChI key

IUJWGLOJJKFASX-UHFFFAOYSA-N

General description

烟酸单核苷酸（NaMN）是在存在磷酸核糖基转移酶（NaPRT）的情况下，由烟酸5-磷酸核糖基-1-焦磷酸（PRPP）通过Preiss-Handler途径形成的。

Application

烟酸单核苷酸已被用作烟酰胺腺嘌呤二核苷酸（NAD）生物合成过程中NMN / NaMN腺苷转移酶（NMNAT）的底物。

Biochem/physiol Actions

烟酸单核苷酸（NaMN）可用于研究酵母中磷酸盐响应信号（PHO）途径与烟碱腺嘌呤二核苷酸（NAD（+））代谢之间的关系。烟酸酯单核苷酸是NMN / NaMN腺苷转移酶（NMNAT）和烟酸酯单核苷酸腺苷转移酶的底物。NaMN酰胺化导致烟酰胺单核苷酸（NMN）的合成，其可进一步转化为NAD辅因子。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000474785

0000462975

0000423196

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Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae.

Shu-Ping Lu et al.

The Journal of biological chemistry, 286(16), 14271-14281 (2011-02-26)

Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor involved in various cellular biochemical reactions. To date the signaling pathways that regulate NAD(+) metabolism remain unclear due to the dynamic nature and complexity of the NAD(+) metabolic pathways and the difficulty

The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.

Kazuo Yamada et al.

Analytical biochemistry, 352(2), 282-285 (2006-04-01)

We have developed a liquid chromatographic-tandem mass spectrometric method that is sensitive and specific and that simultaneously measures cellular NAD(+) and related compounds. Using this method, NAD(+), NAAD, NMN, NAMN, NAM, NA, ADPR, and 5'AMP were first separated over a

Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.

V Sharma et al.

Structure (London, England : 1993), 6(12), 1587-1599 (1998-12-24)

. Mycobacterium tuberculosis is the single most deadly human pathogen and is responsible for nearly three million deaths every year. Recent elucidation of the mode of action of isoniazid, a frontline antimycobacterial drug, suggests that NAD metabolism is extremely critical

Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor.

William B Black et al.

Microbial cell factories, 19(1), 150-150 (2020-07-29)

Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. However, these noncanonical redox cofactors need to be biologically synthesized to achieve

Determining NAD synthesis in erythrocytes.

V Micheli et al.

Methods in enzymology, 280, 211-221 (1997-01-01)

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全球贸易项目编号

货号	GTIN
N7764-25MG	04061834118190
N7764-10MG	04061834118183
N7764-100MG	04061833275689
N7764-5MG	04061834118206

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