生物来源
animal
质量水平
方案
≥98.0% (HPLC)
表单
powder
技术
HPLC: suitable
颜色
white
储存温度
−20°C
SMILES字符串
OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O
InChI
1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)
InChI key
IUJWGLOJJKFASX-UHFFFAOYSA-N
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一般描述
烟酸单核苷酸（NaMN）是在存在磷酸核糖基转移酶（NaPRT）的情况下，由烟酸5-磷酸核糖基-1-焦磷酸（PRPP）通过Preiss-Handler途径形成的。
应用
烟酸单核苷酸已被用作烟酰胺腺嘌呤二核苷酸（NAD）生物合成过程中NMN / NaMN腺苷转移酶（NMNAT）的底物。
生化/生理作用
烟酸单核苷酸（NaMN）可用于研究酵母中磷酸盐响应信号（PHO）途径与烟碱腺嘌呤二核苷酸（NAD（+））代谢之间的关系。 烟酸酯单核苷酸是NMN / NaMN腺苷转移酶（NMNAT）和烟酸酯单核苷酸腺苷转移酶的底物。NaMN酰胺化导致烟酰胺单核苷酸（NMN）的合成，其可进一步转化为NAD辅因子。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae
Kato M and Lin SJ
DNA Repair, 23, 49-58 (2014)
Shin-nosuke Hashida et al.
The Plant journal : for cell and molecular biology, 49(4), 694-703 (2007-02-03)
While mammals and fungi possess nicotinate/nicotinamide mononucleotide adenyltransferase (NMNAT) isoforms, Arabidopsis thaliana only contains a single NMNAT gene, AtNMNAT (At5g55810). We analyzed the enzymatic activity of the AtNMNAT-encoded protein to determine the role of AtNMNAT in plant development. AtNMNAT catalyzed
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis
Sorci L, et al.
Proceedings of the National Academy of Sciences of the USA, 106(9), 3083-3088 (2009)
K Shibata et al.
Journal of chromatography. B, Biomedical sciences and applications, 749(2), 281-285 (2001-01-06)
A system has been developed for the determination of quinolinate phosphoribosyltransferase (QPRT) activity in liver and kidney homogenates using HPLC. A product, nicotinic acid mononucleotide (NaMN), is separated by reversed-phase chromatography (a Tosoh ODS 80TS was used as an analytical
Graham Noctor et al.
Journal of experimental botany, 57(8), 1603-1620 (2006-05-23)
Pyridine nucleotides are key redox carriers in the soluble phase of all living cells, and both NAD and NADP play crucial roles in pro-oxidant and antioxidant metabolism. Recent data also suggest a number of non-redox mechanisms by which these nucleotides
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