N7764
烟酸单核苷酸
别名:
Nicotinate mononucleotide
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关于此项目
经验公式（希尔记法）:
C11H14NO9P
化学文摘社编号:
分子量:
335.20
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥98.0% (HPLC)
Biological source:
animal
Form:
powder
Storage temp.:
−20°C
InChI
1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)
SMILES string
OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O
InChI key
IUJWGLOJJKFASX-UHFFFAOYSA-N
biological source
animal
assay
≥98.0% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
white
storage temp.
−20°C
Quality Level
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General description
烟酸单核苷酸（NaMN）是在存在磷酸核糖基转移酶（NaPRT）的情况下，由烟酸5-磷酸核糖基-1-焦磷酸（PRPP）通过Preiss-Handler途径形成的。
Application
烟酸单核苷酸已被用作烟酰胺腺嘌呤二核苷酸（NAD）生物合成过程中NMN / NaMN腺苷转移酶（NMNAT）的底物。
Biochem/physiol Actions
烟酸单核苷酸（NaMN）可用于研究酵母中磷酸盐响应信号（PHO）途径与烟碱腺嘌呤二核苷酸（NAD（+））代谢之间的关系。 烟酸酯单核苷酸是NMN / NaMN腺苷转移酶（NMNAT）和烟酸酯单核苷酸腺苷转移酶的底物。NaMN酰胺化导致烟酰胺单核苷酸（NMN）的合成，其可进一步转化为NAD辅因子。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Identification of a nicotinamide/nicotinate mononucleotide adenylyltransferase in Giardia lamblia (GlNMNAT)
Forero-Baena N, et al.
Biochimie, 1, 61-69 (2015)
K Shibata et al.
Journal of chromatography. B, Biomedical sciences and applications, 749(2), 281-285 (2001-01-06)
A system has been developed for the determination of quinolinate phosphoribosyltransferase (QPRT) activity in liver and kidney homogenates using HPLC. A product, nicotinic acid mononucleotide (NaMN), is separated by reversed-phase chromatography (a Tosoh ODS 80TS was used as an analytical
Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae
Kato M and Lin SJ
DNA Repair, 23, 49-58 (2014)
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis
Sorci L, et al.
Proceedings of the National Academy of Sciences of the USA, 106(9), 3083-3088 (2009)
Graham Noctor et al.
Journal of experimental botany, 57(8), 1603-1620 (2006-05-23)
Pyridine nucleotides are key redox carriers in the soluble phase of all living cells, and both NAD and NADP play crucial roles in pro-oxidant and antioxidant metabolism. Recent data also suggest a number of non-redox mechanisms by which these nucleotides
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