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Merck
CN

N8133

Nerve Growth Factor from Vipera lebetina venom

lyophilized powder, suitable for cell culture

别名:

NGF

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
Biological source:
Vipera Lebetina
Form:
lyophilized powder
Mol wt:
protein 32.5 kDa
Impurities:
<10 EU/vial
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产品名称

Nerve Growth Factor from Vipera lebetina venom, NGF, lyophilized powder, suitable for cell culture

biological source

Vipera Lebetina

form

lyophilized powder

potency

0.2-20 μg/mL ED50/EC50

quality

endotoxin tested

mol wt

protein 32.5 kDa

packaging

pkg of 0.1 mg

technique(s)

cell culture | mammalian: suitable

impurities

<10 EU/vial

color

white to off-white

UniProt accession no.

storage temp.

−20°C

Quality Level

Physical form

Lyophilized from a 0.2 μm filtered solution in sodium acetate buffer.

Preparation Note

Isolated from the snake venom of V. lebetina.

Analysis Note

The biological activity of Nerve Growth Factor (NGF) from Vipera lebetina venom is measured in a cell proliferation assay using PC-12 cells.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

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Lucy Hepburn et al.
Science (New York, N.Y.), 346(6209), 641-646 (2014-11-02)
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. We have found that the structurally related cystine-knot protein, nerve growth factor
Giusi Prencipe et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3345-3354 (2014-03-04)
Nerve growth factor (NGF) levels are highly increased in inflamed tissues, but their role is unclear. We show that NGF is part of a regulatory loop in monocytes: inflammatory stimuli, while activating a proinflammatory response through TLRs, upregulate the expression
Rachel T Uren et al.
Journal of neurochemistry, 129(4), 614-627 (2014-02-04)
Suppressor of cytokine signaling-2 (SOCS2) is a regulator of intracellular responses to growth factors and cytokines. Cultured dorsal root ganglia neurons from neonatal mice with increased or decreased SOCS2 expression were examined for altered responsiveness to nerve growth factor (NGF).
Tao Yu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 6098-6106 (2014-04-25)
Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degradation of the receptors. However, the in vivo consequences of Trk ubiquitination remain to be addressed. We have developed a mouse model with a mutation in the
Jeremy E Purvis et al.
Cell, 152(5), 945-956 (2013-03-05)
A growing number of studies are revealing that cells can send and receive information by controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we discuss what is known about the dynamics of various signaling networks and

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