N8161
NS309
≥98% (HPLC), Ca2+-activated IK/SK potassium channel activator, solid
别名:
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
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关于此项目
经验公式（希尔记法）:
C8H4Cl2N2O2
CAS Number:
分子量:
231.04
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
NS309, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
yellow
溶解性
DMSO: 22 mg/mL
储存温度
2-8°C
SMILES字符串
O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12
InChI
1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)
InChI key
CVOUSAVHMDXCKG-UHFFFAOYSA-N
生化/生理作用
NS309 is a Ca2+-activated IK/SK potassium channel activator.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
免责声明
air sensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Fan-Fan Li et al.
Placenta, 58, 9-16 (2017-10-01)
Excessive constriction of placental chorionic plate arteries (CPAs) may be associated with preeclampsia (PE). Nitric oxide (NO) as well as intermediate and small Ca The location of IK IK This study provides evidence that dysregulated IK
The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on K
Monika Kloza et al.
Vascular pharmacology, 99, 65-73 (2017-10-19)
The aim of this study was to examine the influence of deoxycorticosterone acetate-salt (DOCA-salt) hypertension and chronic treatment with the fatty acid amide hydrolase inhibitor, URB597, on small and intermediate conductance calcium-activated potassium channels and endothelium-dependent hyperpolarization (K
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null
Abbie C Johnson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2857-2869 (2016-11-07)
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
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