N8161
NS309
≥98% (HPLC), Ca2+-activated IK/SK potassium channel activator, solid
别名:
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
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关于此项目
经验公式（希尔记法）:
C8H4Cl2N2O2
化学文摘社编号:
分子量:
231.04
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
NS309, ≥98% (HPLC), solid
SMILES string
O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12
InChI key
CVOUSAVHMDXCKG-UHFFFAOYSA-N
InChI
1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
DMSO: 22 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
NS309 is a Ca2+-activated IK/SK potassium channel activator.
Disclaimer
air sensitive
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Fan-Fan Li et al.
Placenta, 58, 9-16 (2017-10-01)
Excessive constriction of placental chorionic plate arteries (CPAs) may be associated with preeclampsia (PE). Nitric oxide (NO) as well as intermediate and small Ca The location of IK IK This study provides evidence that dysregulated IK
The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on K
Monika Kloza et al.
Vascular pharmacology, 99, 65-73 (2017-10-19)
The aim of this study was to examine the influence of deoxycorticosterone acetate-salt (DOCA-salt) hypertension and chronic treatment with the fatty acid amide hydrolase inhibitor, URB597, on small and intermediate conductance calcium-activated potassium channels and endothelium-dependent hyperpolarization (K
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
Abbie C Johnson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2857-2869 (2016-11-07)
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high
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