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Merck
CN

N8162

NIDA-41020

≥97% (HPLC), solid

别名:

1-(2,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide

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关于此项目

经验公式（希尔记法）:
C23H24Cl2N4O2
化学文摘社编号:
502486-89-7
分子量:
459.37
NACRES:
NA.77
PubChem Substance ID:
329818682
UNSPSC Code:
12352200
MDL number:
MFCD08277026

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InChI

1S/C23H24Cl2N4O2/c1-15-21(23(30)27-28-12-4-3-5-13-28)26-29(20-11-8-17(24)14-19(20)25)22(15)16-6-9-18(31-2)10-7-16/h6-11,14H,3-5,12-13H2,1-2H3,(H,27,30)

SMILES string

COc1ccc(cc1)-c2c(C)c(nn2-c3ccc(Cl)cc3Cl)C(=O)NN4CCCCC4

InChI key

KWDBQJRWPWTGPF-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~16 mg/mL, H2O: insoluble

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].
NIDA-41020 is a CB1 cannabinoid receptor antagonist.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
011M4615V
115K4600

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Jos H M Lange et al.
Drug discovery today, 10(10), 693-702 (2005-05-18)
The proven clinical efficacy of the CB(1) cannabinoid receptor antagonist rimonabant in both obesity and smoking cessation and its therapeutic potential in other disorders has given a tremendous impetus to the discovery of novel CB(1) antagonists. The number of disclosed
Reeti Katoch-Rouse et al.
Journal of medicinal chemistry, 46(4), 642-645 (2003-02-07)
Exploration of the central CB1 cannabinoid receptors using positron emission tomography (PET) will allow for an understanding of the pharmacological and physiological role played by these receptors in the CNS. Current tracers are highly lipophilic compounds that exhibit very high

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