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N8509

N-亚硝基-N-乙基脲

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别名:

ENU, N-乙基-N-亚硝基脲

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关于此项目

经验公式（希尔记法）:
C3H7N3O2
化学文摘社编号:
759-73-9
分子量:
117.11
NACRES:
NA.25
PubChem Substance ID:
24897681
UNSPSC Code:
12352102
EC Number:
212-072-2
MDL number:
MFCD00053635
Form:
powder
Quality level:
100
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Quality Level

100

form

powder

contains

aqueous acetic acid as stabilizer

storage temp.

−20°C

SMILES string

CCN(N=O)C(N)=O

InChI

1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)

InChI key

FUSGACRLAFQQRL-UHFFFAOYSA-N

Application


  • 通过ENU诱导的致突变和自动减数分裂图谱绘制识别的血压和心率的遗传决定因素。: 该研究利用N-乙基-N-亚硝基脲（ENU）诱导的致突变识别了影响血压和心率的遗传因子。该研究利用利用自动减数分裂图谱绘制来揭示这些心血管特性的遗传基础（Teixeira et al., 2024）。

  • 从对照大鼠和N-乙基-N-亚硝基脲处理大鼠中分离的Hprt 突变T淋巴细胞的克隆性、运输和分子变化。: 该研究考察了ENU对小鼠中T淋巴细胞的克隆性和运输的作用。该研究发现提供了有关 ENU致突变和免疫影响的见解，有助于我们理解化学物质诱导的突变（Judice et al., 2023）。

  • 采用双重测序（duplex sequencing）技术进行遗传毒性测试：研究人员采用接触N-乙基-N-亚硝基脲（ENU）的大鼠进行了概念验证致突变实验。: 该项概念验证研究结合了双重测序技术来测试接触ENU的大鼠的遗传毒性。结果表明了这种方法检测致突变作用的可行性和有效性，彰显了其在遗传毒性评估中的潜力（Smith-Roe et al., 2023）。

Biochem/physiol Actions

在许多动物种属中具有致癌性的 DNA 烷化剂。诱发多种类型的良性和恶性肿瘤，包括神经组织、胃、食管、胰腺、呼吸道、肠、淋巴网状组织、皮肤和肾脏。

Packaging

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signalword

Danger

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

pictograms

Health hazardExclamation mark
GHS08,GHS07

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKDB2110
MKCZ4294
MKCX8074
MKCV6643
MKCT4622

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商品

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

Peng Huang et al.
Journal of genetics and genomics = Yi chuan xue bao, 39(9), 421-433 (2012-10-02)
Zebrafish (Danio rerio) is a well-established vertebrate animal model. A comprehensive collection of reverse genetics tools has been developed for studying gene function in this useful organism. Morpholino is the most widely used reagent to knock down target gene expression
Sukalpa Chattopadhyay et al.
Journal of cell communication and signaling, 13(1), 39-52 (2018-07-07)
The evolutionarily conserved Wnt signaling pathway regulates physiological hematopoiesis, a process of formation of blood cells and has been shown to play crucial role in the development of both myeloid and lymphoid malignancies. The Wnt signaling pathway can be broadly
Daniel R Beisner et al.
The Journal of experimental medicine, 210(1), 23-30 (2012-12-26)
B cell development requires tight regulation to allow for the generation of a diverse repertoire while preventing the development of autoreactive cells. We report, using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis, the identification of a mutant mouse (chompB) with a block in early
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全球贸易项目编号

货号GTIN
N8509-25G04061832863443
N8509-5G04061834118541