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Merck
CN

N8523

Sigma-Aldrich

Monoclonal Anti-NF-κB antibody produced in mouse

clone NF-12, ascites fluid

别名:

Anti-CVID12, Anti-EBP-1, Anti-KBF1, Anti-NF-kB, Anti-NF-kB1, Anti-NF-kappa-B1, Anti-NF-kappaB, Anti-NF-kappabeta, Anti-NFKB-p105, Anti-NFKB-p50, Anti-NFkappaB

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关于此项目

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

NF-12, monoclonal

分子量

antigen 65 kDa

包含

15 mM sodium azide

种属反应性

human, mouse

技术

immunocytochemistry: suitable
microarray: suitable
western blot: 1:1,000 using a whole cell extract from a mouse fibroblast cell line

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... NFKB1(4790)
mouse ... Nfkb1(18033)

一般描述

Monoclonal Anti-NF-κB p65 (mouse IgG1 isotype) is derived from the NF-12 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with a recombinant, mouse NF-κB p65 fragment. Nuclear factor κB (NF-κB1) is a member of NF-κB/Rel family of transcription factors.
Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (NFKB1) is a subunit of nuclear factor κB (NF-κB) and exists as a dimer. It is expressed in the cytosol.

免疫原

recombinant mouse NF-κB p65 fragment (C-terminal, 151 amino acids).

应用

Monoclonal Anti-NF-κB antibody produced in mouse has been used in immunohistochemistry and Western blotting.

生化/生理作用

Nuclear factor kappa-B (NF-κB1) has an ability to affect transcription of κB reporter genes positively or negatively when assayed following transfection.
Nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (NFKB1) has a role in hippocampal neurogenesis. It regulates the signaling by nuclear factor κB (NF-κB). Deletion of the gene in mice leads to defects in innate and adaptive immunity. The protein acts as a mediator of apoptotic response to S-phase DNA damage and replication stress. NFKB1 modulates the structural plasticity of cortical neurons. Knockout of the protein in mice has been shown to cause liver apoptosis and embryonic death.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions
Caamano J and Hunter C A
Clinical Microbiology Reviews, 15(3), 414-429 (2002)
Loss of Nfkb1 leads to early onset aging
Giovanna M. Bernal
Aging, 6(11), 931?942-931?942 (2014)
Cortical Structure Alterations and Social Behavior Impairment in p50-Deficient Mice
Sara Anna Bonini
Cerebral Cortex, 26(6), 2832?2849-2832?2849 (2016)
Cheng Lin et al.
Experimental and therapeutic medicine, 11(4), 1355-1360 (2016-04-14)
The aim of the current study was to observe the effects of simvastatin and taurine on delayed cerebral vasospasm (DCVS) following experimental subarachnoid hemorrhage (SAH) in rabbits. A total of 48 New Zealand white rabbits were allocated at random into
Effects of simvastatin and taurine on delayed cerebral vasospasm following subarachnoid hemorrhage in rabbits
Cheng Lin
Experimental and Therapeutic Medicine, 1355-1360 (2016)

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培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

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