NF 023 hydrate

Name: NF 023 hydrate
Brand: SIGMA

≥98% (HPLC), solid

别名:

8,8′-[Carbonylbis(imino-3,1-phenylene carbonylimino)]bis(1,3,5-naphthalene-trisulfonic acid) hexasodium salt hydrate

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₃₅H₂₀N₄O₂₁S₆ · 6Na · xH₂O

CAS Number:

104869-31-0

分子量:

1162.88 (anhydrous basis)

MDL编号:

MFCD11046019

UNSPSC代码:

12352200

PubChem化学物质编号:

24278597

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

solid

储存条件

desiccated

颜色

white to off-white

溶解性

H₂O: >20 mg/mL

SMILES字符串

O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc5ccc(c6cc(cc(c56)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c3)ccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C35H26N4O21S6.6Na.H2O/c40-33(38-25-7-9-27(63(49,50)51)23-13-21(61(43,44)45)15-29(31(23)25)65(55,56)57)17-3-1-5-19(11-17)36-35(42)37-20-6-2-4-18(12-20)34(41)39-26-8-10-28(64(52,53)54)24-14-22(62(46,47)48)16-30(32(24)26)66(58,59)60;;;;;;;/h1-16H,(H,38,40)(H,39,41)(H2,36,37,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60);;;;;;;1H2/q;6*+1;/p-6

InChI key

FLINBQMOKZJBEC-UHFFFAOYSA-H

基因信息

human ... P2RX1(5023), P2RY1(5028), P2RY11(5032), P2RY2(5029)

应用

NF 023 hydrate has been used as an inhibitor of methyltransferases. It has also been used to test its inhibitory effect on human adenovirus type-37 (HAdV-D37) viral infection in human corneal epithelial (HCE) cells.

生化/生理作用

NF 023 contains six benzene rings and is a suramin analog. It is a potent, competitive, and selective P2X purinoceptor antagonist that aids in discriminating between P2X receptor subtypes.

特点和优势

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.