N8784
去甲斑蝥素
solid
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关于此项目
经验公式（希尔记法）:
C8H8O4
化学文摘社编号:
分子量:
168.15
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
SMILES字符串
O=C1OC(=O)C2C3CCC(O3)C12
InChI
1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2
InChI key
JAABVEXCGCXWRR-UHFFFAOYSA-N
基因信息
human ... PPP2R5A(5525)
一般描述
去甲斑蝥素 (NCTD) 是斑蝥素 (CTD) 的脱甲基衍生物。
应用
去甲斑蝥素已被用于原代细胞培养和治疗。它还被用于皮下接种Huh7细胞的小鼠。
生化/生理作用
去甲斑蝥素是一种潜在的抗肿瘤药物。去甲斑蝥素通过刺激细胞自噬和凋亡来阻断 SK-N-SH 神经母细胞瘤细胞的生长。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--毒素类产品
此项目有
Liping Deng et al.
Expert opinion on therapeutic patents, 21(11), 1743-1753 (2011-10-25)
Norcantharidin (7-oxabicyclo [2.2.1] heptane-2,3-dicarboxylic anhydride) is the demethylated form of cantharidin. Norcantharidin not only has strong anticancer activity, but also eliminates most side-effects in the urinary system, does not cause myelosuppression and increases the number of white blood cells. With
Yu-Jen Chen et al.
PloS one, 7(5), e37006-e37006 (2012-05-23)
Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined the effect
Min Guan et al.
Nanomedicine : nanotechnology, biology, and medicine, 8(7), 1172-1181 (2012-02-11)
N-Trimethyl chitosan (TMC) was synthesized and used to prepare lactosyl-norcantharidin TMC nanoparticles (Lac-NCTD-TMC-NPs) using an ionic cross-linkage process. Lac-NCTD-TMC-NPs with an average particle size of 120.6 ± 1.7 nm were obtained, with an entrapment efficiency of 69.29% ± 0.76%, and
Chung-Hsin Yeh et al.
Chinese journal of integrative medicine, 18(9), 676-682 (2012-09-01)
To investigate the inhibitory activities of norcantharidin (NCTD), a demethylated analogue of cantharidin, on Hep3B cells (a human hepatoma cell line) with deficiency of p53. The survival rate of the Hep3B cells after treating with NCTD was measured by MTT
Rebekah E Wharton et al.
Toxins, 11(12) (2019-12-19)
Microcystins (MC) and nodularin (NOD) are toxins released by cyanobacteria during harmful algal blooms. They are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A) and cause a variety of adverse symptoms in humans and animals if ingested.
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