N9158
N-(NBD-Aminolauroyl)ceramide
≥98%
别名:
C12-NBD Ceramide, N-[12-[(7-Nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-ceramide
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选择尺寸
关于此项目
经验公式（希尔记法）:
C36H61N5O6
分子量:
659.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
InChI
1S/C36H61N5O6/c1-2-3-4-5-6-7-8-9-10-12-15-18-21-24-33(43)31(29-42)38-34(44)25-22-19-16-13-11-14-17-20-23-28-37-30-26-27-32(41(45)46)36-35(30)39-47-40-36/h21,24,26-27,31,33,37,42-43H,2-20,22-23,25,28-29H2,1H3,(H,38,44)/b24-21+/t31-,33+/m0/s1
SMILES string
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCCCCCCNc1ccc([N+]([O-])=O)c2nonc12
InChI key
SNOJCYCOPNIGIK-ULETYAGTSA-N
assay
≥98%
form
solid
shipped in
dry ice
storage temp.
−20°C
Quality Level
General description
Fluorescently labeled fatty acid sphingolipid membrane probe. NBD group excitation 460 nm, emission 534 nm.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Shaalee Dworski et al.
Biochimica et biophysica acta, 1863(2), 386-394 (2016-12-05)
Acid Ceramidase Deficiency (Farber disease, FD) is an ultra-rare Lysosomal Storage Disorder that is poorly understood and often misdiagnosed as Juvenile Idiopathic Arthritis (JIA). Hallmarks of FD are accumulation of ceramides, widespread macrophage infiltration, splenomegaly, and lymphocytosis. The cytokines involved
Cassandra Suhrland et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 108(3), 1141-1156 (2019-08-25)
The bioactive sphingolipid ceramide has many important roles in cell signaling processes, particularly in signaling programmed cell death in cancer. However, ceramide levels are often impaired in multi-drug resistant and radiation resistant cancers due to the dysregulation of ceramide metabolism.
Anis Ahmad et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(2), 771-780 (2016-11-12)
The molecular mechanisms responsible for the development of proteinuria and glomerulosclerosis in radiation nephropathy remain largely unknown. Podocytes are increasingly recognized as key players in the pathogenesis of proteinuria in primary and secondary glomerular disorders. The lipid-modulating enzyme sphingomyelin phosphodiesterase
Paola Palumbo et al.
International journal of molecular sciences, 20(12) (2019-06-23)
The relevance of nitric oxide synthase 2 (NOS2) as a prognostic factor in Glioblastoma Multiforme (GBM) malignancy is emerging. We analyzed the effect of NOS2 inhibitor 1400W on the autophagic flux and extracellular vesicle (EV) secretion in U87MG glioma cells.
Wataru Sakamoto et al.
Journal of lipid research, 59(11), 2116-2125 (2018-08-30)
Ceramidases hydrolyze ceramides into sphingosine and fatty acids, with sphingosine being further metabolized into sphingosine-1-phosphate (S1P); thus, ceramidases control the levels of these bioactive sphingolipids in cells and tissues. Neutral ceramidase (nCDase) is highly expressed in colorectal tissues, and a
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