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安全信息

N9653

Sigma-Aldrich

纺锤霉素 二盐酸盐

from Streptomyces netropsis, ≥98% (HPLC and TLC), powder

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别名:
Congocidin, Sinanomycin
经验公式（希尔记法）:
C18H26N10O3 · 2HCl
CAS号:
18133-22-7
分子量:
503.39
PubChem化学物质编号:
24897909
NACRES:
NA.77

生物来源

Streptomyces netropsis

质量水平

200

检测方案

≥98% (HPLC and TLC)

形式

powder

颜色

faintly yellow

溶解性

H2O: 1 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
viruses

作用机制

DNA synthesis | interferes

储存温度

−20°C

SMILES字符串

[H]Cl.[H]Cl.NC(CCNC(C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2C)=O)=CN1C)=O)=N

InChI

1S/C18H26N10O3.2ClH/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22;;/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24);2*1H

InChI key

SDRHUASONSRLFR-UHFFFAOYSA-N

生化/生理作用

Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.

注意

Protect from light.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

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Ben L Kelly et al.
PloS one, 6(6), e21412-e21412 (2011-07-07)
AT-rich DNA, and the proteins that bind it (AT-hook proteins), modulate chromosome structure and function in most eukaryotes. Unlike other trypanosomatids, the genome of Leishmania species is unusually GC-rich, and the regulation of Leishmania chromosome structure, replication, partitioning is not
Federico Riccardi Sirtori et al.
ChemMedChem, 7(6), 1112-1122 (2012-04-11)
Postreplicative mismatch repair (MMR) is a cellular system involved in the recognition and correction of DNA polymerase errors that escape detection in proofreading. Of the various mismatched bases, T:G pairing in DNA is one of the more common mutations leading
N P Bazhulina et al.
Biofizika, 57(2), 232-242 (2012-05-19)
Data obtained show that antiviral activities of bis-linked netropsin derivatives are targeted by specific complexes formed by helicase UL9 of herpes simplex virus type 1 with viral DNA replication origins, represented by two OriS sites and one OriL site. According
M Poot et al.
Experimental cell research, 218(1), 326-330 (1995-05-01)
DNA topoisomerases are enzymes governing the multitude of conformational changes DNA undergoes during the cell cycle. Several compounds are likely to interfere with specific steps of the catalytic cycle of these enzymes. Camptothecin arrests the activity of DNA topoisomerase I
T A Beerman et al.
Biochimica et biophysica acta, 1090(1), 52-60 (1991-08-27)
This study examined the ability of netropsin and related minor groove binders to interfere with the actions of DNA topoisomerases II and I. We evaluated a series of netropsin dimers linked with flexible aliphatic chains of different lengths. These agents
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