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Merck
CN

N9879

NADase from porcine brain

≥0.007 unit/mg solid

别名:

DPN Nucleosidase, NAD+ glycohydrolase

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥0.007 unit/mg solid
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form

powder

specific activity

≥0.007 unit/mg solid

solubility

insoluble

storage temp.

−20°C

Quality Level

General description

NADase is a glycohydrolase that catalyzes ADP-ribose transfer.

Application

NADase from porcine brain has been used in a study to investigate histidine and related compounds resulting from catalyzed ADP-riboslyation. It has also been used in a study to investigate the preparation of arylazide-substituted pyridine adenine dinucleotides for photoaffinity labeling.

Biochem/physiol Actions

Nicotinamide has been shown to inhibit NADase activity.

Physical form

Acetone-dried powder

Other Notes

One unit will hydrolyze 1.0 μmole of β-NAD to nicotinamide and ADP-ribose per min at pH 7.3 at 37 °C.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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D San Segundo et al.
Transplantation proceedings, 44(9), 2676-2678 (2012-11-14)
Posttransplant infection after lung transplantation is a common feature due to the immunodeficiency induced by the immunosuppressive load. To assess B-cell subsets in lung transplant recipients suffering at least one episode of infection within the first year posttransplantation. Twenty-eight lung
H Kim et al.
Molecular and cellular biochemistry, 138(1-2), 237-243 (1994-09-01)
NAD glycohydrolases are the longest known enzymes that catalyze ADP-ribose transfer. The function of these ubiquitous, membrane-bound enzymes has been a long standing puzzle. The NAD glycohydrolases are briefly reviewed in light of the discovery by our laboratory that NAD
Julien Calvo et al.
PloS one, 7(11), e50495-e50495 (2012-12-05)
Hematopoietic stem cells are responsible for the generation of the entire blood system through life. This characteristic relies on their ability to self renew and on their multi-potentiality. Thus quantification of the number of hematopoietic stem cells in a given
Evidence for Enzymatic ADP-Ribosylation to Histidine and Related Dipeptides
Tono-oka, S., et al.
Acta Chemica Scandinavica, 48, 780-782 (1994)
K A Wall et al.
The Biochemical journal, 335 ( Pt 3), 631-636 (1998-10-31)
Carba-NAD and pseudocarba-NAD are carbocyclic analogues of NAD+ in which a 2,3-dihydroxycyclopentane methanol replaces the beta-d-ribonucleotide ring of the nicotinamide riboside moiety of NAD+ [Slama and Simmons (1988) Biochemistry 27, 183-193]. These carbocyclic NAD+ analogues, related to each other as

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