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Merck
CN

O0877

恶喹酸

quinolone antibiotic

别名:

5,8-二氢-5-乙基-8-氧代-1,3-二氧戊环并[4,5-g]喹啉-7-羧酸

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关于此项目

经验公式(希尔记法):
C13H11NO5
化学文摘社编号:
分子量:
261.23
UNSPSC Code:
51282935
NACRES:
NA.85
PubChem Substance ID:
EC Number:
238-750-8
Beilstein/REAXYS Number:
620635
MDL number:
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Quality Level

antibiotic activity spectrum

Gram-negative bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12

InChI

1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)

InChI key

KYGZCKSPAKDVKC-UHFFFAOYSA-N

General description

化学结构:喹诺酮

Application

恶喹酸被用于研究大肠杆菌(Escherichia coli)和肠沙门氏菌(Salmonella enterica)中的新型传染性抗性机制qnrA、qnrB、qnrS和aac(6′)Ib-cr。将恶喹酸加入培养基中,可用于分离阴道加德纳菌(Gardnerella vaginalis

Biochem/physiol Actions

恶喹酸是一种喹诺酮类抗生素。它是一种DNA促旋酶(拓扑异构酶II)抑制剂,可用于研究DNA缠绕和卷曲,并作为多巴胺再摄取抑制剂,用于多巴胺能神经传递过程的研究。

Other Notes

5g,25g
保存于密闭容器内,置于干燥通风处。


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

农药列管产品

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历史批次信息供参考:

分析证书(COA)

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相关内容

Product Information Sheet


J S Thompson
Journal of clinical microbiology, 21(5), 843-843 (1985-05-01)
Colistin-oxolinic acid medium is proposed as a selective isolation medium for Gardnerella vaginalis. The medium is effective in inhibiting staphylococci and gram-negative bacteria while allowing growth of G. vaginalis.
Xiuhong Wang et al.
The Journal of antimicrobial chemotherapy, 65(3), 520-524 (2010-01-14)
Quinolone-mediated death of Escherichia coli has been proposed to occur by two pathways. One is blocked by inhibitors of protein synthesis; the other is not. It is currently unknown how these two pathways fit with the recent observation that hydroxyl
Quoc Tuc Dinh et al.
Talanta, 85(3), 1238-1245 (2011-08-03)
This study presents the development of an automated on-line solid phase extraction (SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of 23 antibiotics in environmental water samples. After optimisation of LC-MS/MS conditions, SPE parameters such as sorbent type, sample



全球贸易项目编号

货号GTIN
O0877-25G04061834212652
O0877-5G04061835507078