O0877
恶喹酸
quinolone antibiotic
别名:
5,8-二氢-5-乙基-8-氧代-1,3-二氧戊环并[4,5-g]喹啉-7-羧酸
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关于此项目
经验公式（希尔记法）:
C13H11NO5
化学文摘社编号:
分子量:
261.23
UNSPSC Code:
51282935
NACRES:
NA.85
PubChem Substance ID:
EC Number:
238-750-8
Beilstein/REAXYS Number:
620635
MDL number:
产品名称
恶喹酸, quinolone antibiotic
InChI key
KYGZCKSPAKDVKC-UHFFFAOYSA-N
InChI
1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
SMILES string
CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
Quality Level
antibiotic activity spectrum
Gram-negative bacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
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Application
恶喹酸被用于研究大肠杆菌（Escherichia coli）和肠沙门氏菌（Salmonella enterica）中的新型传染性抗性机制qnrA、qnrB、qnrS和aac(6′)Ib-cr。将恶喹酸加入培养基中，可用于分离阴道加德纳菌（Gardnerella vaginalis）。
Biochem/physiol Actions
恶喹酸是一种喹诺酮类抗生素。它是一种DNA促旋酶（拓扑异构酶II）抑制剂，可用于研究DNA缠绕和卷曲，并作为多巴胺再摄取抑制剂，用于多巴胺能神经传递过程的研究。
General description
化学结构：喹诺酮
Other Notes
5g,25g
保存于密闭容器内，置于干燥通风处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
农药列管产品
此项目有
J S Thompson
Journal of clinical microbiology, 21(5), 843-843 (1985-05-01)
Colistin-oxolinic acid medium is proposed as a selective isolation medium for Gardnerella vaginalis. The medium is effective in inhibiting staphylococci and gram-negative bacteria while allowing growth of G. vaginalis.
J Garcia de Mateos-Verchere et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(4), 255-259 (1999-02-03)
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in locomotor activity. This stimulation culminated at the 32 mg/kg dose and became smaller for higher doses (64-128 mg/kg). When opposed to increasing doses (50-100-200 microg/kg
Takashi Aoki et al.
Marine biotechnology (New York, N.Y.), 13(4), 629-638 (2010-04-16)
Shrimp aquaculture is one of the major foodproducing industries in the world. However, it is being impacted by several problems including diseases, antibiotic use, and environmental factors. The extent of the effects of these problems in the immune system of
Quoc Tuc Dinh et al.
Talanta, 85(3), 1238-1245 (2011-08-03)
This study presents the development of an automated on-line solid phase extraction (SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of 23 antibiotics in environmental water samples. After optimisation of LC-MS/MS conditions, SPE parameters such as sorbent type, sample
Alketa Tarushi et al.
Journal of inorganic biochemistry, 103(6), 898-905 (2009-04-28)
The neutral mononuclear zinc complexes with the quinolone antibacterial drug oxolinic acid in the absence or presence of a nitrogen donor heterocyclic ligand 2,2'-bipyridine or 1,10-phenanthroline have been synthesized and characterized. The experimental data suggest that oxolinic acid is on
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