O100
氧化震颤素M
muscarinic acetylcholine receptor agonist, solid
别名:
N,N,N,-三甲基-4-(2-氧代-1-吡咯烷基)-2-丁炔-1-碘化铵, 氧化震颤素甲碘化物
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C11H19IN2O
化学文摘社编号:
分子量:
322.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
产品名称
氧化震颤素M, solid
form
solid
Quality Level
color
white
solubility
H2O: 24 mg/mL, ethanol: 4.6 mg/mL
storage temp.
2-8°C
SMILES string
[I-].C[N+](C)(C)CC#CCN1CCCC1=O
InChI
1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
InChI key
VVLMSCJCXMBGDI-UHFFFAOYSA-M
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
Application
氧化震颤素M已用作毒蕈碱型乙酰胆碱受体(mAchR)激动剂：
- 用于研究其对秀丽隐杆线虫移动的急性效应
- 用于处理海马体神经元，以便研究成纤维细胞生长因子受体1(FGFR1)的磷酸化作用
- 用于诱发大鼠膀胱过度活动症
Biochem/physiol Actions
氧化震颤素M是一种非选择性毒蕈碱型乙酰胆碱受体激动剂。
Features and Benefits
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M Gillard et al.
Molecular pharmacology, 32(1), 100-108 (1987-07-01)
We compared the binding characteristics of muscarinic receptors labeled by [3H]oxotremorine-M ([3H]oxo-M) in homogenates of brain cortex and heart from rat. In both tissues [3H]oxo-M bound, with the same KD (6.5 nM), to a fraction of the receptors labeled by
Yoshihiro Matsumoto et al.
Urology, 75(4), 862-867 (2010-02-17)
To investigate the effects of various muscarinic acetylcholine receptor (mAChR) antagonists, including selective M2 and M3 mAChR antagonists, on bladder overactivity. It has been proposed that the urothelium modulates the activity of bladder afferent pathways. However, the differential roles of
David R Thomas et al.
Neuropharmacology, 58(8), 1206-1214 (2010-03-09)
N-desmethylclozapine (NDMC) has been reported to display partial agonism at the human recombinant and rat native M(1) mAChR, a property suggested to contribute to the clinical efficacy of clozapine. However, the profile of action of NDMC at the human native
Tanya L Daigle et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11461-11466 (2012-08-17)
Although G-protein-coupled receptor kinase 2 (GRK2) is the most widely studied member of a family of kinases that has been shown to exert powerful influences on a variety of G-protein-coupled receptors, its role in the brain remains largely unknown. Here
V Di Liberto et al.
Biochimica et biophysica acta. General subjects, 1861(2), 235-245 (2016-11-07)
Recently, it was demonstrated that G-protein-coupled receptors (GPCRs) can transactivate tyrosine kinase receptors in absence of their ligands. In this work, driven by the observation that mAChRs and fibroblast growth factor receptors (FGFRs) share signalling pathways and regulation of brain
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O100-100MG | 04061834212690 |
| O100-500MG | 04061838065063 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持