O100
氧化震颤素M
muscarinic acetylcholine receptor agonist, solid
别名:
N,N,N,-三甲基-4-(2-氧代-1-吡咯烷基)-2-丁炔-1-碘化铵, 氧化震颤素甲碘化物
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关于此项目
经验公式（希尔记法）:
C11H19IN2O
化学文摘社编号:
分子量:
322.19
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
氧化震颤素M, solid
表单
solid
质量水平
颜色
white
溶解性
H2O: 24 mg/mL
ethanol: 4.6 mg/mL
储存温度
2-8°C
SMILES字符串
[I-].C[N+](C)(C)CC#CCN1CCCC1=O
InChI
1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
InChI key
VVLMSCJCXMBGDI-UHFFFAOYSA-M
基因信息
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
应用
氧化震颤素M已用作毒蕈碱型乙酰胆碱受体(mAchR)激动剂：
- 用于研究其对秀丽隐杆线虫移动的急性效应
- 用于处理海马体神经元，以便研究成纤维细胞生长因子受体1(FGFR1)的磷酸化作用
- 用于诱发大鼠膀胱过度活动症
生化/生理作用
氧化震颤素M是一种非选择性毒蕈碱型乙酰胆碱受体激动剂。
特点和优势
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
David R Thomas et al.
Neuropharmacology, 58(8), 1206-1214 (2010-03-09)
N-desmethylclozapine (NDMC) has been reported to display partial agonism at the human recombinant and rat native M(1) mAChR, a property suggested to contribute to the clinical efficacy of clozapine. However, the profile of action of NDMC at the human native
Detection of Fibroblast Growth Factor Receptor 1 (FGFR1) Transactivation by Muscarinic Acetylcholine Receptors (mAChRs) in Primary Neuronal Hippocampal Cultures Through Use of Biochemical and Morphological Approaches
"Reference Module in Food Science, 57-70 (2018)
M Gillard et al.
Molecular pharmacology, 32(1), 100-108 (1987-07-01)
We compared the binding characteristics of muscarinic receptors labeled by [3H]oxotremorine-M ([3H]oxo-M) in homogenates of brain cortex and heart from rat. In both tissues [3H]oxo-M bound, with the same KD (6.5 nM), to a fraction of the receptors labeled by
Simona Dedoni et al.
Journal of neurochemistry, 122(1), 58-71 (2012-04-27)
Type I interferons (IFNs) have been shown to act on neurons and to cause neuronal damage through mechanisms not completely defined. Here, we investigated the effects of type I IFNs on brain-derived neurotrophic factor (BDNF)-induced TrkB receptor signaling and neurotrophic
Yoshihiro Matsumoto et al.
Urology, 75(4), 862-867 (2010-02-17)
To investigate the effects of various muscarinic acetylcholine receptor (mAChR) antagonists, including selective M2 and M3 mAChR antagonists, on bladder overactivity. It has been proposed that the urothelium modulates the activity of bladder afferent pathways. However, the differential roles of
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