产品名称
油酰辅酶 A 锂盐, ≥90% (HPLC)
Quality Level
assay
≥90% (HPLC)
form
powder
solubility
H2O: soluble-50 mg/mL, clear, colorless
storage temp.
−20°C
Application
辅酶 A 作为酰基载体,乙酰辅酶 A 发挥作用。油酰辅酶 A 可能用于研究酰基辅酶 A:胆固醇酰基转移酶 1 (ACAT1) 等酶参与长链脂肪酸胆固醇酯化的特异性和动力学。
Biochem/physiol Actions
油酰辅酶A是一种重要的底物,对于1-烷基-2,3-二酰甘油(ADG)和哈德氏腺(HG)1-烷基-2,3-二酰甘油的超长链单不饱和脂肪酸的生物合成至关重要。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Chengcheng Guan et al.
Nature communications, 11(1), 2478-2478 (2020-05-20)
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage. SOAT1 is a target to treat several
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs.
Leon C, Hill JS, Wasan KM.
Pharmaceut. Res., 22, 1578-1588 (2005)
Ta-Yuan Chang et al.
American journal of physiology. Endocrinology and metabolism, 297(1), E1-E9 (2009-01-15)
The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles
Mariana Igoillo-Esteve et al.
International journal for parasitology, 41(3-4), 429-438 (2010-12-18)
Metabolism in trypanosomatids is compartmentalised with major pathways, notably glycolysis, present in peroxisome-like organelles called glycosomes. To date, little information is available about the transport of metabolites through the glycosomal membrane. Previously, three ATP-binding cassette (ABC) transporters, called GAT1-3 for
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2, 3-diacylglycerol
Miyazaki M, et al.
The Journal of Biological Chemistry, 276(42), 39455-39461 (2001)
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