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Merck
CN

O1257

油酸-水溶性

powder, BioReagent, suitable for cell culture

别名:

油酸-环糊精复合物

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关于此项目

MDL编号:
MFCD00064242
UNSPSC代码:
12352211
PubChem化学物质编号:
24897936
NACRES:
NA.75

主要文件

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生物来源

synthetic (organic)

质量水平

200

产品线

BioReagent

表单

powder

组成

Oleic acid, ~30 mg/g (balance methyl-β-cyclodextrin)

技术

cell culture | mammalian: suitable

溶解性

H2O: 50 mg/mL, clear to slightly hazy

储存温度

−20°C

SMILES字符串

CCCCCCCC\C=C/CCCCCCCC(O)=O

InChI

1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-

InChI key

ZQPPMHVWECSIRJ-KTKRTIGZSA-N

基因信息

human ... SOAT1(6646), SOAT2(8435)

相关类别

应用

十八烯酸水溶液可用于：
  • 制备用于细胞处理的FFA（游离脂肪酸）混合物
  • 研究其对L6肌细胞中溶质载体家族2成员4 (SLC2A4)/GLUT4表达的影响，并用作潜在的转录调控因子
  • 制备脂肪培养基，用于诱导原代人肝细胞的体外脂肪变性

其他说明

甲基-β-环葡聚糖结合改善了油酸在培养基中的溶解度和运输。

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000442408
0000442408
0000431445
0000431445
0000300019

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A20 attenuates FFAs-induced lipid accumulation in nonalcoholic steatohepatitis
Ai L, et al.
International Journal of Biological Sciences, 11(12), 1436-1436 (2015)
Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells
Poletto A C, et al.
Molecular and Cellular Endocrinology, 401(12), 65-72 (2015)
Shuo Li et al.
International journal of biological sciences, 17(15), 4165-4175 (2021-11-23)
Background: Inflammation and apoptosis play a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Suppressor of cytokine signaling 2 (SOCS2) is one of classic negative regulators of cytokine signaling, which has recently been described as anti-inflammatory mediators. However, the
Pu Sun et al.
Journal for immunotherapy of cancer, 9(8) (2021-08-11)
The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME
An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells
Boteon YL, et al.
PLoS ONE, 13(7), e0201419-e0201419 (2018)
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商品

Oleic Acid in Cell Culture

How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.

Stearic Acid in Cell Culture

Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.

油酸在细胞培养中的应用

不饱和脂肪酸、油酸和其他细胞培养成分如何影响无血清、无蛋白细胞培养系统（用于生物制造包括单克隆抗体在内的异源蛋白）的性能。

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