OPC 31260 盐酸盐

Name: OPC 31260 盐酸盐
Brand: SIGMA

≥98% (HPLC)

别名:

5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride, Mozavaptan hydrochloride, N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride

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About This Item

经验公式（希尔记法）:

C₂₇H₂₉N₃O₂ · HCl

CAS Number:

138470-70-9

分子量:

464.00

MDL编号:

MFCD11111965

UNSPSC代码:

51111800

PubChem化学物质编号:

329818895

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

DMSO: ≥15 mg/mL

储存温度

2-8°C

SMILES字符串

Cl.CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c4ccccc14

InChI

1S/C27H29N3O2.ClH/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30;/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31);1H

InChI key

MOROBKPIULFQDC-UHFFFAOYSA-N

生化/生理作用

OPC 31260 is a vasopressin V2 selective antagonist. Arginine vasopressin (AVP) plays an important part in circulatory and water homeostasis. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. OPC-31260 has been shown to inhibit the development of polycystic kidney disease in several animal models.

Vasopressin V2 selective antagonist.