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O1877

赭曲霉毒素A

Name: 赭曲霉毒素A
Brand: SIGMA

from Petromyces albertensis, ≥98% (HPLC), powder, mycotoxin

别名:

N-[(3R)-(5-氯-8-羟基-3-甲基-1-氧代-7-异苯并二氢吡喃基)羰基]-L-苯丙氨酸

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₈ClNO₆

化学文摘社编号:

303-47-9

分子量:

403.81

NACRES:

NA.77

PubChem Substance ID:

24897954

UNSPSC Code:

12352200

MDL number:

MFCD00078079

Beilstein/REAXYS Number:

1301486

Assay:

≥98% (HPLC)

Form:

powder

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属性

产品名称

赭曲霉毒素A, from Petromyces albertensis, ≥98% (HPLC)

biological source

Petromyces albertensis

Quality Segment

300

assay

≥98% (HPLC)

form

powder

impurities

Benzene, free

solubility

ethanol: soluble

mode of action

enzyme | inhibits, protein synthesis | interferes

storage temp.

2-8°C

SMILES string

C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O

InChI

1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1

InChI key

RWQKHEORZBHNRI-BMIGLBTASA-N

说明

Application

Ochratoxin A has been used as a mycotoxin:

to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells
to test its cytotoxic effects in bovine mammary epithelial cells
as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells

Biochem/physiol Actions

Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species. It is immunotoxic, teratogenic myelotoxic, and mutagenic. It effectively interrupts the intestinal barrier functions. OTA displays a long elimination half-life and stimulates the major inflammatory cytokines release.

Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca²⁺ pump activity.

Preparation Note

This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).

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Hazard Classifications

Acute Tox. 2 Oral - Carc. 2

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H351

pcodes

P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c