O2260
Mouse Osteopontin
recombinant, expressed in NSO cells, powder, suitable for cell culture
别名:
Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)
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关于此项目
Biological source:
mouse
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Mol wt:
30 kDa by SDS-PAGE (reducing), 65 kDa by SDS-PAGE (reducing) (doublet)
Assay:
>95% (SDS-PAGE)
产品名称
Osteopontin from mouse, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
biological source
mouse
recombinant
expressed in NSO cells
sterility
sterile
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
30 kDa by SDS-PAGE (reducing), 65 kDa by SDS-PAGE (reducing) (doublet)
packaging
pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Spp1(20750)
Analysis Note
The biological activity is measured by its ability to mediate 293 cell adhesion.
Application
Osteopontin from mouse has been used:
- to study its role in a mouse model of preterm brain injury
- as a positive control to analyze the relationship between the vascular calcification process and osteopontin (OPN) overexpression in the neointima of atherosclerotic plaques
- to study its interaction on the crystal growth process of hydroxyapatite in agarose hydrogels
Biochem/physiol Actions
Osteopontin (OPN) is a secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig and bovine OPN share 40% amino acid sequence identity.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
此项目有
Osteopontin upregulation in atherogenesis is associated with cellular oxidative stress triggered by the activation of scavenger receptors
Jimenez CAE, et al.
Archives of Medical Research, 43(2), 102-111 (2012)
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
Denhardt DT, et al.
The Journal of Clinical Investigation, 107(9), 1055-1061 (2001)
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury
Albertsson AM, et al.
Journal of Neuroinflammation, 11(1), 197-197 (2014)
Effect of osteopontin, chondroitin sulfates (B, C), and human serum albumin on the crystallization behavior of hydroxyapatite in agarose and silica hydrogels
Jimenez CAE, et al.
Crystal Growth & Design, 8(4), 1335-1339 (2008)
Yunan Zhu et al.
Japanese journal of infectious diseases, 68(6), 467-473 (2015-04-14)
The level of osteopontin (OPN) increases during bacterial lung infection. However, the OPN level in virus-induced lung injury is unclear, and the relationship between the hyer-production of OPN and lung injury remains to be thoroughly understood. Therefore, we sought to
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