O3011
Oxiracetam
别名:
4-Hydroxy-2-oxopyrrolidine-N-acetamide
储存温度
2-8°C
SMILES字符串
NC(=O)CN1CC(O)CC1=O
InChI
1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
InChI key
IHLAQQPQKRMGSS-UHFFFAOYSA-N
生化/生理作用
Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.
Nootropic agent, improves learning and memory.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Y Lu et al.
Brain research, 768(1-2), 197-207 (1997-11-22)
Previous studies demonstrated that DBA/2J (DBA) mice performed poorly while C57BL/6J (C57) mice performed normally on a number of complex learning and memory tasks. Chronic oxiracetam treatment dramatically improved the performance of DBA mice but not that of C57 mice
A Pittaluga et al.
European journal of pharmacology, 272(2-3), 203-209 (1995-01-16)
Oxiracetam, aniracetam and D-cycloserine, three putative cognition enhancers, were examined in a functional assay for NMDA receptors. Rat hippocampal slices or synaptosomes were labeled with [3H]noradrenaline and exposed to NMDA or glutamate in superfusion. NMDA (100 microM) elicited a remarkable
X L Jiao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 29(8), 570-575 (1994-01-01)
A method was developed for the determination of oxiracetam concentration in serum and urine by HPLC. Acyclovir was used as an internal standard. The analytical column was a stainless-steel column (30 mm x 4.6 mm ID) filled with 10 microns
M Raiteri et al.
Neuroscience letters, 145(1), 109-113 (1992-09-28)
The effects of the nootropic drug oxiracetam on the K(+)-evoked overflow of [3H]D-aspartic acid ([3H]D-ASP), [3H]acetylcholine ([3H]ACh), [3H] gamma-aminobutyric acid ([3H]GABA), [3H]noradrenaline ([3H]NA) and [3H]5-hydroxytryptamine ([3H]5-HT) have been studied in superfused rat hippocampal slices. The overflow of [3H]D-ASP was enhanced
R C Simpson et al.
Journal of chromatography, 631(1-2), 227-232 (1993-02-12)
Reversed-phase HPLC methodology utilizing pre-column derivatization and post-column reaction fluorimetric detection has been developed and applied to the determination of oxiracetam in human plasma. The method involves preliminary isolation of oxiracetam and internal standard from plasma by solid-phase extraction prior
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