O3011
Oxiracetam
别名:
4-Hydroxy-2-oxopyrrolidine-N-acetamide
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关于此项目
经验公式（希尔记法）:
C6H10N2O3
化学文摘社编号:
分子量:
158.16
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
SMILES string
NC(=O)CN1CC(O)CC1=O
InChI key
IHLAQQPQKRMGSS-UHFFFAOYSA-N
storage temp.
2-8°C
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Biochem/physiol Actions
Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.
Nootropic agent, improves learning and memory.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Z Hlinák et al.
European journal of pharmacology, 314(1-2), 1-7 (1996-10-24)
In the present study, the elevated plus-maze was used to evaluate memory in female mice. In Experiment 1, the mice retested on day 1, 4 or 7 after the initial session escaped from the open arm into the enclosed arm
L de Angelis et al.
Neurobiology of learning and memory, 64(2), 119-124 (1995-09-01)
The effects of a nootropic drug, oxiracetam (50-100-200 mg/kg ip), and a potent antioxidant agent, ascorbic acid (62.5-125-250 mg/kg ip), administered alone or in combination, were investigated on scopolamine-induced amnesia in a mouse habituation test. The light-dark aversion test was
I N Krylov et al.
Biulleten' eksperimental'noi biologii i meditsiny, 115(3), 260-262 (1993-03-01)
Acute exposure of rats to microwaves (12.6 chr, 2375 MHz, power density 1 mW/cm2) induced the retrograde amnesia. It was show the role of opioidergic, benzodiazepine, GABAergic and cholinergic components in the amnesic effects of microwaves. Piracetam (100 mg/kg, i.
A Mancini et al.
Psychoneuroendocrinology, 21(7), 621-629 (1996-10-01)
Previous studies have shown that food ingestion is not capable of inhibiting the GHRH-induced GH release in anorexia nervosa, at variance with what is observed in normal subjects. Moreover, a cholinergic alteration has been hypothesized in this disorder. In a
C Mondadori et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(6), 2041-2045 (1994-03-15)
Many theories of memory postulate that processing of information outlasts the learning situation and involves several different physiological substrates. If such physiologically distinct mechanisms or stages of memory do in fact exist, they should be differentially affected by particular experimental
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