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Merck
CN

O3251

催产素

别名:

α-多巴胺, 催产激素

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关于此项目

经验公式（希尔记法）:
C43H66N12O12S2
化学文摘社编号:
50-56-6
分子量:
1007.19
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
24897975
EC Number:
200-048-4
Beilstein/REAXYS Number:
3586108
MDL number:
MFCD00076731
Biological source:
synthetic (organic)
Form:
lyophilized powder
Assay:
≥97% (HPLC)

主要文件

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InChI key

XNOPRXBHLZRZKH-DSZYJQQASA-N

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

SMILES string

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥97% (HPLC)

form

lyophilized powder

UniProt accession no.

P01178
P30559
P70536

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... OXT(5020), OXTR(5021)
rat ... Oxtr(25342)

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相关类别

Biochem/physiol Actions

刺激子宫收缩和哺乳；增加Na+ 排泄；刺激子宫肌层GTP酶和磷脂酶 C。
Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Application

Oxytocin has been used in experimental study to induce uterine contractions in rats. It has been used in comet assay to determine the number of cells with DNA damage.

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Physical form

Supplied as a powder with a peptide content of ≥ 75%

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000496751
0000496751
0000489773
0000489770
0000489771

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Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment.
Stanic D
Chemico-Biological Interactions, 256, 134-141 (2016)
Yuetao Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(12), 1095-1104 (2013-06-29)
To examine the efficacy of YuanHu painkillers (YHP) as a treatment for primary dysmenorrhea and to reveal YHP's principle formula. A Wistar rat uterine contraction model was utilized in this study. Rats were given 0.698g/kg YHP, 0.07g/kg tetrahydropalmatine (THP; YHP's
The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization.
Rao VV
Cytogenetics and Cell Genetics, 61(4), 271-273 (1992)
Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion.
Ventura RR
Brazilian journal of medical and biological research, 35(9), 1101-1109 (2002)
Decreased levels of serum oxytocin in pediatric patients with Attention Deficit/Hyperactivity Disorder.
Sasaki T
Psychiatry Research, 228(3), 746-751 (2015)
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