O3514
Bovine Osteopontin
from bovine milk, powder, suitable for cell culture
别名:
Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)
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关于此项目
Biological source:
bovine milk
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Mol wt:
~60 kDa (reducing conditions)
Assay:
>85% (by SDSPAGE under reducing conditions and visualized by silver stain)
产品名称
Osteopontin from bovine milk, lyophilized powder
biological source
bovine milk
Quality Segment
sterility
sterile
assay
>85% (by SDSPAGE under reducing conditions and visualized by silver stain)
form
lyophilized powder
mol wt
~60 kDa (reducing conditions)
packaging
pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
shipped in
ambient
storage temp.
-10 to -25°C
Gene Information
cow ... SPP1(281499)
General description
Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.
Biochem/physiol Actions
Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.
A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to mediate 293 cell adhesion.
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
Eyeshields, Gloves, type N95 (US)