O4126
草酰乙酸
≥97% (HPLC)
别名:
2-氧代丁二酸, 丁酮二酸, 氧代丁二酸, 草醋酸
登录 查看组织和合同定价。
选择尺寸
关于此项目
线性分子式:
HOOCCH2COCOOH
化学文摘社编号:
分子量:
132.07
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
206-329-8
Beilstein/REAXYS Number:
1705475
MDL number:
Application
草酰乙酸已被用作测定胞质杂合体和神经母细胞瘤细胞中柠檬酸合酶活性的底物。它也已被用于测定苹果酸脱氢酶的活化。
Biochem/physiol Actions
草酰乙酸是三羧酸循环的一个中间体，对新陈代谢至关重要。它是糖异生途径的一部分。丙酮酸羧化酶的突变会导致草酰乙酸的产生减少。它可抑制琥珀酸脱氢酶，是线粒体代谢的一种关键调节剂。
General description
草酰乙酸是一种二羧酸。它是柠檬酸循环中的一个中间体。它高度溶于水，并且大量存在。它通过丙酮酸羧化酶对丙酮酸的作用，在线粒体中产生。草酰乙酸的分解产物包括苹果酸、丙酮酸和天冬氨酸。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Alexander K H Weiss et al.
Bioscience reports, 40(3) (2020-02-19)
FAH domain containing protein 1 (FAHD1) is a mammalian mitochondrial protein, displaying bifunctionality as acylpyruvate hydrolase (ApH) and oxaloacetate decarboxylase (ODx) activity. We report the crystal structure of mouse FAHD1 and structural mapping of the active site of mouse FAHD1.
MitoTALEN: a general approach to reduce mutant mtDNA loads and restore oxidative phosphorylation function in mitochondrial diseases
Hashimoto M, et al.
Molecular Therapy, 23(10), 15921599-15921599 (2015)
Oxaloacetic acid supplementation as a mimic of calorie restriction
Cash A
Open Longevity Science, 3, 2227-2227 (2009)
Synergistic coordination of polyethylene glycol with ClpB/DnaKJE bichaperone for refolding of heat-denatured malate dehydrogenase
Nian R, et al.
Biotechnology Progress, 25(4), 10781085-10781085 (2009)
Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex IIdriven respiration
Fink BD, et al.
The Journal of Biological Chemistry, 293(51), 1993219941-1993219941 (2018)
商品
Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
本文介绍了增殖活性细胞为何需要碳源和氮源合成大分子。尽管大部分肿瘤细胞利用有氧糖酵解途径并分流线粒体氧化磷酸化代谢物，但许多肿瘤细胞表现出线粒体活性增加。
实验方案
Spectrophotometric assay evaluates malic dehydrogenase activity using bovine heart enzyme with critical histidine residue at active site.
相关内容
Product Information Sheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持