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O4375

催产素

Name: 催产素
Brand: SIGMA

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

别名:

α-多巴胺, 催产激素

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关于此项目

经验公式（希尔记法）:

C₄₃H₆₆N₁₂O₁₂S₂

化学文摘社编号:

50-56-6

分子量:

1007.19

UNSPSC Code:

51111800

NACRES:

NA.32

PubChem Substance ID:

24897994

MDL number:

MFCD00076731

Beilstein/REAXYS Number:

3586108

Biological source:

synthetic

Form:

lyophilized powder

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biological source

synthetic

Quality Level

200

sterility

non-sterile

form

lyophilized powder

specific activity

~15 IU/mg solid (Prepared from synthetic oxytocin)

solubility

water: 10 mg/mL, clear, colorless

UniProt accession no.

P01178, P30559, P70536

shipped in

ambient

storage temp.

2-8°C

SMILES string

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

InChI key

XNOPRXBHLZRZKH-DSZYJQQASA-N

Gene Information

human ... OXT(5020), OXTR(5021)
rat ... Oxtr(25342)

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General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Application

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

刺激子宫收缩和哺乳；增加Na⁺ 排泄；刺激子宫肌层GTP酶和磷脂酶 C。

Physical form

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs.

Mia E Persson et al.

Hormones and behavior, 95, 85-93 (2017-08-03)

The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor

The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization.

Rao VV

Cytogenetics and Cell Genetics, 61(4), 271-273 (1992)

Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion.

Ventura RR

Brazilian journal of medical and biological research, 35(9), 1101-1109 (2002)

Motherhood and oxytocin receptor genetic variation are associated with selective changes in electrocortical responses to infant facial expressions.

Mikko J Peltola et al.

Emotion (Washington, D.C.), 14(3), 469-477 (2014-04-23)

Recent studies suggest that parental caregiving is associated with adaptive changes in neurocognitive responses to emotional cues and oxytocin function, possibly reflecting the increased need of parents to monitor infants' emotional states. In the current study, we investigated whether the

Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation

Green KA

Developmental Biology, 299(1), 164-175 (2006)

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全球贸易项目编号

货号	GTIN
O4375-250IU	04061834233824
O4375-1000IU	04061834233800

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