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Merck
CN

O5254

Sigma-Aldrich

Oxazepam

GABAA ligand, powder

别名:

7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-1,4(2H)-benzodiazepin-2-one

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关于此项目

经验公式（希尔记法）:
C15H11ClN2O2
CAS Number:
604-75-1
分子量:
286.71
EC 号:
210-076-9
MDL编号:
MFCD00057903
UNSPSC代码:
12352200
PubChem化学物质编号:
24898014
NACRES:
NA.77

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Product Name

Oxazepam,

表单

powder

质量水平

200

药品控制

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

SMILES字符串

OC1N=C(c2ccccc2)c3cc(Cl)ccc3NC1=O

InChI

1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)

InChI key

ADIMAYPTOBDMTL-UHFFFAOYSA-N

基因信息

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

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生化/生理作用

Anxiolytic; ligand for the GABAA receptor benzodiazepine modulatory site.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险声明

H336,H351

危险分类

Carc. 2 - STOT SE 3

靶器官

Central nervous system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000242987
0000243929
0000232516
0000242987
0000243929

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B Olivier et al.
European journal of pharmacology, 358(2), 117-128 (1998-11-10)
The involvement of the GABA(A)-benzodiazepine receptor complex in rat pup ultrasonic vocalisations was studied by testing benzodiazepine receptor ligands with varying intrinsic activity and selectivity for benzodiazepine subtype receptors. Ultrasonic vocalisations were recorded under two temperature conditions (37 degrees C
Olof Beck et al.
Scandinavian journal of clinical and laboratory investigation, 74(8), 681-686 (2014-07-22)
Products for on-site urine drug testing offer the possibility to perform screening for drugs of abuse directly at the point-of-care. This is a well-established routine in emergency and dependency clinics but further evaluation of performance is needed due to inherent
T Brodin et al.
Science (New York, N.Y.), 339(6121), 814-815 (2013-02-16)
Environmental pollution by pharmaceuticals is increasingly recognized as a major threat to aquatic ecosystems worldwide. A variety of pharmaceuticals enter waterways by way of treated wastewater effluents and remain biochemically active in aquatic systems. Several ecotoxicological studies have been done
Josef Skoda et al.
Cells, 9(12) (2020-12-02)
The constitutive androstane receptor (CAR) is the essential regulator of genes involved both in xenobiotic and endobiotic metabolism. Diazepam has been shown as a potent stimulator of CAR nuclear translocation and is assumed as an indirect CAR activator not interacting
J Sonne
Pharmacology & toxicology, 73 Suppl 1, 1-23 (1993-01-01)
The aim of the present work was to investigate the impact of disease states and environmental and host factors on the glucuronidation of oxazepam. Glucuronidation represents quantitatively one of the most important metabolic conjugation pathways (phase II) in man for
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