O6881
奥昔嘌醇
≥98% (HPLC)
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关于此项目
经验公式（希尔记法）:
C5H4N4O2
化学文摘社编号:
分子量:
152.11
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
219-570-9
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Solubility:
1 M NaOH: 49.00-51.00 mg/mL, clear to slightly hazy, colorless to yellow (heated NaOH)
产品名称
奥昔嘌醇, ≥98% (HPLC)
InChI key
HXNFUBHNUDHIGC-UHFFFAOYSA-N
InChI
1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
SMILES string
O=C1NC(=O)c2cn[nH]c2N1
assay
≥98% (HPLC)
form
powder
solubility
1 M NaOH: 49.00-51.00 mg/mL, clear to slightly hazy, colorless to yellow (heated NaOH)
Quality Level
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Application
氧嘌呤醇已被用作黄嘌呤氧化酶抑制剂，以评估其对肝癌细胞增殖的影响。它也已被用作黄嘌呤抑制剂，以阐明其在诱导hpv16晚期基因表达中的作用。
氧嘌呤醇是一种别嘌呤醇代谢产物，被用作抑制剂来研究黄嘌呤氧化酶的特异性和动力学。氧嘌呤醇还通过抑制黄嘌呤氧化酶而用作抗炎药。
Biochem/physiol Actions
一种别嘌醇的代谢产物。
氧嘌呤醇具有刺激成骨细胞分化和增强骨形成的能力。用于治疗痛风和高尿酸血症。氧嘌呤醇被认为是一种强抗氧化剂。它能阻止成骨细胞黄嘌呤氧化酶（XO）的作用。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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International journal of cancer, 131(9), 2187-2196 (2012-02-18)
Cachexia is a common co-morbidity in cancer occurring in up to 80% of patients depending on the type of cancer. Uric acid (UA), the end-product of the purine metabolism, is elevated in cachexia due to tissue wasting and upregulated xanthine
Sophie L Stocker et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(25), 2363-2368 (2010-08-13)
Oxypurinol is the active metabolite of allopurinol which is used to treat hyperuricaemia associated with gout. Both oxypurinol and allopurinol inhibit xanthine oxidase which forms uric acid from xanthine and hypoxanthine. Plasma oxypurinol concentrations vary substantially between individuals and the
Sophie L Stocker et al.
The Journal of rheumatology, 38(5), 904-910 (2011-02-03)
To investigate the pharmacokinetic and pharmacodynamic interaction between probenecid and oxypurinol (the active metabolite of allopurinol) in patients with gout. This was an open-label observational clinical study. Blood and urine samples were collected to measure oxypurinol and urate concentrations. We
Adenosine causes read-through into the late region of the HPV16 genome in a guanosine-dependent manner
Yu H, et al.
Virology, 521(9), 1-19 (2018)
Jan B Derks et al.
Pediatric research, 68(5), 374-380 (2010-07-09)
In complicated labor, neonatal outcome may depend not only on the extent of fetal asphyxia and acidosis but also on the effects on the fetal cardiovascular system of reactive oxygen species (ROS) generated during the ischemia-reperfusion (I/R) associated with repeated
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