O6881
奥昔嘌醇
≥98% (HPLC)
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C5H4N4O2
化学文摘社编号:
分子量:
152.11
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
219-570-9
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Solubility:
1 M NaOH: 49.00-51.00 mg/mL, clear to slightly hazy, colorless to yellow (heated NaOH)
Application
氧嘌呤醇已被用作黄嘌呤氧化酶抑制剂，以评估其对肝癌细胞增殖的影响。它也已被用作黄嘌呤抑制剂，以阐明其在诱导hpv16晚期基因表达中的作用。
氧嘌呤醇是一种别嘌呤醇代谢产物，被用作抑制剂来研究黄嘌呤氧化酶的特异性和动力学。氧嘌呤醇还通过抑制黄嘌呤氧化酶而用作抗炎药。
Biochem/physiol Actions
氧嘌呤醇具有刺激成骨细胞分化和增强骨形成的能力。用于治疗痛风和高尿酸血症。氧嘌呤醇被认为是一种强抗氧化剂。它能阻止成骨细胞黄嘌呤氧化酶（XO）的作用。
一种别嘌醇的代谢产物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Allopurinol and oxypurinol promote osteoblast differentiation and increase bone formation
Orriss I R, et al.
Experimental Cell Research, 342(2), 166-174 (2016)
Xanthine dehydrogenase downregulation promotes TGF beta signaling and cancer stem cell-related gene expression in hepatocellular carcinoma
Chen GL, et al.
Oncogenesis, 6(9), e382-e382 (2017)
Umair Z Malik et al.
Free radical biology & medicine, 51(1), 179-184 (2011-05-11)
Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) that contribute to vascular inflammation. Binding of XO to vascular endothelial cell glycosaminoglycans (GAGs) results in significant resistance to inhibition by traditional pyrazolopyrimidine-based inhibitors such as allopurinol. Therefore
Paolo Puddu et al.
Journal of cardiology, 59(3), 235-242 (2012-03-09)
Uric acid is the end product of purine metabolism. Its immediate precursor, xanthine, is converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric acid has been formerly considered a major antioxidant in human plasma with possible beneficial
Sophie L Stocker et al.
The Journal of rheumatology, 38(5), 904-910 (2011-02-03)
To investigate the pharmacokinetic and pharmacodynamic interaction between probenecid and oxypurinol (the active metabolite of allopurinol) in patients with gout. This was an open-label observational clinical study. Blood and urine samples were collected to measure oxypurinol and urate concentrations. We
相关内容
Product Information Sheet
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O6881-500MG | 04061833612446 |
| O6881-100MG | 04061834248347 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持